Department of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 300, Philadelphia, PA, 19107, USA.
J Neuroinflammation. 2024 Nov 19;21(1):301. doi: 10.1186/s12974-024-03295-1.
Interleukin-37 (IL-37) has anti-inflammatory properties in innate and adaptive immunity. Patients with multiple sclerosis (MS), an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), have increased serum levels of IL-37. However, it is unknown whether IL-37 has an inhibitory effect on ongoing autoimmune neuroinflammation, thus offering a potential MS therapy.
Here, we examined the effect of IL-37 in an experimental autoimmune encephalomyelitis (EAE) model after disease onset to determine if it was protective.
IL-37-treated mice developed a less severe disease than control mice, with reduced demyelination as determined by increased expression of myelin basic protein. IL-37 suppressed inflammation by decreasing infiltration of CD4 + T cells into the CNS and increasing the frequency of regulatory T cells, while IL-10 expression by CD4 + T cells decreased over time in the CNS.
Our findings confirm the immunomodulatory role of IL-37 in CNS inflammation during ongoing disease, thus indicating the potential of IL-37 as an inhibitory reagent for MS therapy.
白细胞介素-37（IL-37）在先天和适应性免疫中具有抗炎特性。多发性硬化症（MS）患者，即中枢神经系统（CNS）的自身免疫性炎症性脱髓鞘疾病，其血清 IL-37 水平升高。然而，目前尚不清楚 IL-37 是否对正在进行的自身免疫性神经炎症具有抑制作用，从而提供一种潜在的 MS 治疗方法。
本研究旨在观察 IL-37 在疾病发作后的实验性自身免疫性脑脊髓炎（EAE）模型中的作用，以确定其是否具有保护作用。
与对照组相比，IL-37 治疗组的小鼠疾病严重程度较轻，髓鞘碱性蛋白表达增加表明脱髓鞘程度降低。IL-37 通过减少 CD4+T 细胞向中枢神经系统的浸润和增加调节性 T 细胞的频率来抑制炎症，而 CNS 中 CD4+T 细胞的 IL-10 表达随时间推移而减少。
我们的研究结果证实了 IL-37 在中枢神经系统炎症中的免疫调节作用，这表明 IL-37 作为 MS 治疗的抑制试剂具有潜在作用。
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