Institute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, 55131 Mainz, Germany; Department of Dermatology and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine, University Hospital of Cologne, 50937 Cologne, Germany.
Hamburg Center for Translational Immunology (HCTI) and Section of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Cell Rep. 2022 Mar 29;38(13):110565. doi: 10.1016/j.celrep.2022.110565.
Interleukin (IL)-10 is considered a prototypical anti-inflammatory cytokine, significantly contributing to the maintenance and reestablishment of immune homeostasis. Accordingly, it has been shown in the intestine that IL-10 produced by Tregs can act on effector T cells, thereby limiting inflammation. Herein, we investigate whether this role also applies to IL-10 produced by T cells during central nervous system (CNS) inflammation. During neuroinflammation, both CNS-resident and -infiltrating cells produce IL-10; yet, as IL-10 has a pleotropic function, the exact contribution of the different cellular sources is not fully understood. We find that T-cell-derived IL-10, but not other relevant IL-10 sources, can promote inflammation in experimental autoimmune encephalomyelitis. Furthermore, in the CNS, T-cell-derived IL-10 acts on effector T cells, promoting their survival and thereby enhancing inflammation and CNS autoimmunity. Our data indicate a pro-inflammatory role of T-cell-derived IL-10 in the CNS.
白细胞介素 (IL)-10 被认为是一种典型的抗炎细胞因子，对维持和重新建立免疫稳态有重要作用。因此，在肠道中已经表明，Treg 产生的 IL-10 可以作用于效应 T 细胞，从而限制炎症。在这里，我们研究了这一作用是否也适用于中枢神经系统 (CNS) 炎症期间 T 细胞产生的 IL-10。在神经炎症中，中枢神经系统驻留细胞和浸润细胞都会产生 IL-10；然而，由于 IL-10 具有多种功能，不同细胞来源的确切贡献尚不完全清楚。我们发现 T 细胞衍生的 IL-10 但不是其他相关的 IL-10 来源，可以促进实验性自身免疫性脑脊髓炎中的炎症。此外，在中枢神经系统中，T 细胞衍生的 IL-10 作用于效应 T 细胞，促进其存活，从而增强炎症和中枢神经系统自身免疫。我们的数据表明 T 细胞衍生的 IL-10 在中枢神经系统中具有促炎作用。
