Perinatal Oral Health, Eastman Institute for Oral Health, University of Rochester Medical Center, 625 Elmwood Ave, Rochester, NY, 14620, USA.
College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
BMC Oral Health. 2024 Nov 19;24(1):1410. doi: 10.1186/s12903-024-05197-3.
Silver Diamine Fluoride (SDF) is effective for arresting dental caries, presenting a valuable non-invasive treatment option in dentistry. Despite its therapeutic advantages, a significant drawback is the tooth discoloration that follows its application, which can affect patient acceptance. Addressing this aesthetic concern without diminishing the treatment's efficacy remains challenging in dental practice. This study explores strategies to improve the aesthetic outcomes of SDF treatments.
This in vitro study assessed the efficacy of Zinc in reducing SDF-induced discoloration on dentin blocks and examined its impact on the physical properties of dentin, including hardness and roughness. Dentin blocks were pre-treated with various concentrations of Zinc, followed by SDF application. Color changes were analyzed using Image J software, and cytotoxicity was evaluated using the CytoTox-ONE™ Homogeneous Membrane Integrity Assay. Dentin surface characteristics, including micro-hardness and roughness, were assessed using scanning electron microscopy.
The study results revealed a dose-dependent efficacy of Zinc in reducing discoloration caused by SDF on dentin, with higher Zinc concentrations showing better improvement in color outcomes. The application of a 20 M Zinc solution prior to SDF treatment significantly reduced discoloration compared to SDF alone, measured on day 14. Additionally, no significant changes in the hardness or roughness of etched dentin were observed in Zinc + SDF group compared to the SDF alone group. Zinc treatments demonstrated a desirable outcome on mucosal cytotoxicity, comparable to that of the negative control.
Zinc significantly reduced SDF-induced tooth discoloration in a dose-dependent manner without affecting the etched dentin's micro-hardness and roughness, potentially improving patient acceptance, especially in visible areas of the mouth. Further research is warranted to validate the effectiveness of this zinc-enhanced treatment protocol in vivo.
Zinc-enhanced SDF treatments could enhance patient acceptance, especially in visible areas of the mouth, offering an improved option for caries management.
银胺氟化物 (SDF) 对抑制龋齿有效，为牙科提供了一种有价值的非侵入性治疗选择。尽管它具有治疗优势，但一个显著的缺点是应用后会导致牙齿变色，这可能会影响患者的接受度。在牙科实践中，如何在不降低治疗效果的情况下改善 SDF 治疗的美学效果仍然具有挑战性。本研究探讨了改善 SDF 治疗美学效果的策略。
本体外研究评估了锌对减少 SDF 引起的牙本质变色的效果，并研究了其对牙本质物理性能（包括硬度和粗糙度）的影响。牙本质块用不同浓度的锌进行预处理，然后应用 SDF。使用 Image J 软件分析颜色变化，使用 CytoTox-ONE™ 均质膜完整性测定法评估细胞毒性。使用扫描电子显微镜评估牙本质表面特性，包括显微硬度和粗糙度。
研究结果表明，锌对减少 SDF 引起的牙本质变色具有剂量依赖性，较高浓度的锌显示出更好的颜色改善效果。与单独使用 SDF 相比，在 SDF 治疗前应用 20 M 锌溶液可显著减少 14 天时的变色。与单独使用 SDF 组相比，在锌 + SDF 组中，未观察到蚀刻牙本质的硬度或粗糙度有显著变化。锌处理对黏膜细胞毒性表现出良好的效果，与阴性对照组相当。
锌可显著减少 SDF 诱导的牙齿变色，呈剂量依赖性，而不影响蚀刻牙本质的显微硬度和粗糙度，可能会提高患者的接受度，特别是在口腔可见区域。需要进一步的研究来验证这种增强锌的 SDF 治疗方案在体内的有效性。
增强 SDF 治疗的锌处理方法可以提高患者的接受度，特别是在口腔可见区域，为龋齿管理提供了一种更好的选择。
