Kamo Alaa, Ates Sonmezoglu Ozlem, Sonmezoglu Savas
Nanotechnology R&D Laboratory, Karamanoglu Mehmetbey University 70100 Karaman Turkey
Department of Bioengineering, Karamanoglu Mehmetbey University 70100 Karaman Turkey.
Nanoscale Adv. 2024 Nov 11;6(23):6008-6018. doi: 10.1039/d4na00811a. eCollection 2024 Nov 19.
Hospital-acquired infections (HAIs), especially nosocomial infections caused by antibiotic-resistant bacteria, are one of the most pressing health problems in all societies. Therefore, there is an urgent need to develop novel disinfection methods as alternatives to antibiotics to act against multidrug-resistant bacterial strains. Even though the photocatalytic disinfection phenomenon has been considered as a viable alternative compared to other proposed solutions, there is still a need to develop innovative functional materials for improving its efficacy under visible light to have a comparable impact to UV radiation. To boost the antibacterial efficacy under visible light, herein, we developed hydrothermally ternary zinc-tin-oxide (ZnSnO) nanoparticles modified with magnesium (Mg) ions at different doping ratios (0.5%, 1.0%, 1.5%, and 2.0%) as a photocatalytic disinfection agent and utilized it for the first time to kill Gram-negative () and Gram-positive () pathogens that cause nosocomial infections. Moreover, we also explored how these materials interact with organic pollutants in the presence of visible light. Mg cationic ions significantly enhanced the photocatalytic efficiency of ZTO nanoparticles under visible light to achieve 98% degradation of RhB dye in just 100 min, and rapidly produced numerous hydroxyl radicals as the main reactive oxygen species (ROS) responsible for the degradation, playing a key role in the nanoparticles impressive disinfection efficacy against these pathogenic bacteria. More importantly, Mg@ZTO nanoparticles could effectively kill 99.76% of and 96.96% of within only 1 h under visible light due to their smaller particle size, larger surface area, low recombination rate and greater ROS generation with oxygen vacancies. This research suggests that Mg-doped ZTO nanoparticles might be a viable and highly effective photocatalytic antibacterial agent candidate for future commercialization in healthcare and environmental applications.
医院获得性感染（HAIs），尤其是由耐抗生素细菌引起的医院感染，是所有社会中最紧迫的健康问题之一。因此，迫切需要开发新的消毒方法作为抗生素的替代品，以对抗多重耐药细菌菌株。尽管与其他提出的解决方案相比，光催化消毒现象被被一种一种可行的替代方案，但仍需要开发创新的功能材料，以提高其在可见光下的功效，使其对紫外线辐射具有可比的影响。为了提高可见光下的抗菌效果，在此，我们水热合成了不同掺杂比例（0.5%、1.0%、1.5%和2.0%）的镁（Mg）离子修饰的三元锌锡氧化物（ZnSnO）纳米颗粒作为光催化消毒剂，并首次将其用于杀灭引起医院感染的革兰氏阴性菌（）和革兰氏阳性菌（）病原体。此外，我们还研究了这些材料在可见光存在下如何与有机污染物相互作用。镁阳离子显著提高了ZTO纳米颗粒在可见光下的光催化效率，在100分钟内实现了98%的RhB染料降解，并迅速产生大量羟基自由基作为负责降解的主要活性氧物种（ROS），在纳米颗粒对这些病原菌的显著消毒效果中起关键作用。更重要的是，Mg@ZTO纳米颗粒由于其较小的粒径、较大的表面积、较低的复合率以及因氧空位产生更多的ROS，在可见光下仅1小时内就能有效杀灭99.76%的和96.96%的。这项研究表明，镁掺杂的ZTO纳米颗粒可能是一种可行且高效的光催化抗菌剂候选物，有望在未来的医疗保健和环境应用中实现商业化。
