• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

自身免疫性肺泡蛋白沉积症中的全肺灌洗：资源有限环境下的独特挑战

Whole Lung Lavage in Autoimmune Pulmonary Alveolar Proteinosis: Unique Challenges in a Resource-Limited Setting.

作者信息

Dhungana Ashesh, Lamichhane Buddhi Sagar, Shrestha Prajowl, Shrestha Deepa Kumari, Oli Ritamvara, Dhungana Shreya, Bista Pratibha

机构信息

Department of Medicine - Chest Unit, Bir Hospital National Academy of Medical Sciences Kathmandu Nepal.

Department of Pathology, Bir Hospital National Academy of Medical Sciences Kathmandu Nepal.

出版信息

Clin Case Rep. 2024 Nov 18;12(11):e9588. doi: 10.1002/ccr3.9588. eCollection 2024 Nov.

DOI:10.1002/ccr3.9588
PMID:39563859
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11573727/
Abstract

Autoimmune pulmonary alveolar proteinosis (PAP) is characterized by antibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), alveolar macrophage dysfunction, and surfactant accumulation. Whole lung lavage (WLL) is the treatment of choice in patients with PAP and severe hypoxemia. In resource-limited settings, WLL can be performed in the intubated, anesthetized patient who is being one lung ventilated using a Y-type bladder irrigation catheter for saline instillation and drainage.

摘要

自身免疫性肺泡蛋白沉积症（PAP）的特征是存在抗粒细胞-巨噬细胞集落刺激因子（GM-CSF）抗体、肺泡巨噬细胞功能障碍和表面活性剂积聚。全肺灌洗（WLL）是PAP合并严重低氧血症患者的首选治疗方法。在资源有限的情况下，对于正在接受单肺通气的插管麻醉患者，可使用Y型膀胱冲洗导管进行生理盐水滴注和引流，从而实施全肺灌洗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b658/11573727/454b9263e2a1/CCR3-12-e9588-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b658/11573727/17b6c334828d/CCR3-12-e9588-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b658/11573727/f317031b46b9/CCR3-12-e9588-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b658/11573727/a6f079322a85/CCR3-12-e9588-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b658/11573727/21fa7881d547/CCR3-12-e9588-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b658/11573727/454b9263e2a1/CCR3-12-e9588-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b658/11573727/17b6c334828d/CCR3-12-e9588-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b658/11573727/f317031b46b9/CCR3-12-e9588-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b658/11573727/a6f079322a85/CCR3-12-e9588-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b658/11573727/21fa7881d547/CCR3-12-e9588-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b658/11573727/454b9263e2a1/CCR3-12-e9588-g004.jpg

相似文献

1
Whole Lung Lavage in Autoimmune Pulmonary Alveolar Proteinosis: Unique Challenges in a Resource-Limited Setting.自身免疫性肺泡蛋白沉积症中的全肺灌洗：资源有限环境下的独特挑战
Clin Case Rep. 2024 Nov 18;12(11):e9588. doi: 10.1002/ccr3.9588. eCollection 2024 Nov.
2
Combined-modality therapy for pulmonary alveolar proteinosis in a remote setting: a case report.偏远地区肺泡蛋白沉积症的联合治疗模式：一例报告。
BMC Pulm Med. 2019 Mar 12;19(1):61. doi: 10.1186/s12890-019-0822-x.
3
A case of autoimmune pulmonary alveolar proteinosis with severe respiratory failure treated with segmental lung lavage and oral statin therapy.一例采用肺段灌洗和口服他汀类药物治疗的自身免疫性肺泡蛋白沉积症伴严重呼吸衰竭病例。
Respir Med Case Rep. 2022 Jun 6;38:101684. doi: 10.1016/j.rmcr.2022.101684. eCollection 2022.
4
Sequential Granulocyte-Macrophage Colony-Stimulating Factor Inhalation after Whole-Lung Lavage for Pulmonary Alveolar Proteinosis. A Report of Five Intractable Cases.序贯粒细胞-巨噬细胞集落刺激因子吸入治疗全肺灌洗后肺泡蛋白沉积症：5 例难治性病例报告。
Ann Am Thorac Soc. 2017 Aug;14(8):1298-1304. doi: 10.1513/AnnalsATS.201611-892BC.
5
Granulocyte-Macrophage Colony-Stimulating Factor Inhalation Therapy for Severe Pulmonary Alveolar Proteinosis.粒细胞-巨噬细胞集落刺激因子吸入疗法治疗重症肺泡蛋白沉积症
Am J Ther. 2020 Mar 25;28(2):e171-e178. doi: 10.1097/MJT.0000000000001053.
6
Whole lung lavage and GM-CSF use for pulmonary alveolar proteinosis in an infant with lysinuric protein intolerance: a case report.婴儿赖氨酸尿蛋白不耐受致肺泡蛋白沉积症：全肺灌洗及 GM-CSF 应用 1 例报告。
Ital J Pediatr. 2024 Jun 3;50(1):111. doi: 10.1186/s13052-024-01677-y.
7
Pulmonary alveolar proteinosis: time to shift?肺泡蛋白沉积症：是时候做出改变了吗？
Expert Rev Respir Med. 2015 Jun;9(3):337-49. doi: 10.1586/17476348.2015.1035259. Epub 2015 Apr 12.
8
Ten-year experience of whole lung lavage in pediatric Pulmonary Alveolar Proteinosis.儿童肺泡蛋白沉积症全肺灌洗 10 年经验。
Klin Padiatr. 2024 Feb;236(2):64-72. doi: 10.1055/a-2194-3467. Epub 2024 Jan 23.
9
Inhaled recombinant GM-CSF reduces the need for whole lung lavage and improves gas exchange in autoimmune pulmonary alveolar proteinosis patients.吸入重组 GM-CSF 可减少全肺灌洗的需求并改善自身免疫性肺泡蛋白沉积症患者的气体交换。
Eur Respir J. 2024 Jan 4;63(1). doi: 10.1183/13993003.01233-2023. Print 2024 Jan.
10
Whole lung lavage combined with Granulocyte-macrophage colony stimulating factor inhalation for an adult case of refractory pulmonary alveolar proteinosis.全肺灌洗联合吸入粒细胞巨噬细胞集落刺激因子治疗1例成人难治性肺泡蛋白沉积症
BMC Pulm Med. 2014 May 19;14:87. doi: 10.1186/1471-2466-14-87.

本文引用的文献

1
How We Do It: Whole Lung Lavage.我们的做法：全肺灌洗。
Sarcoidosis Vasc Diffuse Lung Dis. 2022;39(2):e2022017. doi: 10.36141/svdld.v39i2.12884. Epub 2022 Jun 29.
2
Inhaled GM-CSF for Pulmonary Alveolar Proteinosis.吸入 GM-CSF 治疗肺泡蛋白沉积症。
N Engl J Med. 2019 Sep 5;381(10):923-932. doi: 10.1056/NEJMoa1816216.
3
Whole-lung lavage for severe pulmonary alveolar proteinosis assisted by veno-venous extracorporeal membrane oxygenation: a case report.静脉-静脉体外膜肺氧合辅助下全肺灌洗治疗重症肺泡蛋白沉积症：1例报告
Can J Respir Ther. 2018 Dec;55(1):9-12. doi: 10.29390/cjrt-2018-019. Epub 2018 Dec 5.
4
Whole lung lavage-technical details, challenges and management of complications.全肺灌洗——技术细节、挑战及并发症处理
J Thorac Dis. 2017 Jun;9(6):1697-1706. doi: 10.21037/jtd.2017.04.10.
5
Sequential Granulocyte-Macrophage Colony-Stimulating Factor Inhalation after Whole-Lung Lavage for Pulmonary Alveolar Proteinosis. A Report of Five Intractable Cases.序贯粒细胞-巨噬细胞集落刺激因子吸入治疗全肺灌洗后肺泡蛋白沉积症：5 例难治性病例报告。
Ann Am Thorac Soc. 2017 Aug;14(8):1298-1304. doi: 10.1513/AnnalsATS.201611-892BC.
6
Whole lung lavage therapy for pulmonary alveolar proteinosis: a global survey of current practices and procedures.肺泡蛋白沉积症的全肺灌洗治疗：当前实践与操作的全球调查
Orphanet J Rare Dis. 2016 Aug 31;11(1):115. doi: 10.1186/s13023-016-0497-9.
7
Pulmonary Alveolar Proteinosis Syndrome.肺泡蛋白沉积症综合征
Clin Chest Med. 2016 Sep;37(3):431-40. doi: 10.1016/j.ccm.2016.04.006. Epub 2016 Jun 17.
8
Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia.局部麻醉下肺泡蛋白沉积症的序贯支气管镜肺灌洗
Lung India. 2015 Mar-Apr;32(2):162-4. doi: 10.4103/0970-2113.152636.
9
Bilateral whole lung lavage in pulmonary alveolar proteinosis--a retrospective study.肺泡蛋白沉积症双侧全肺灌洗术——一项回顾性研究
Rev Port Pneumol. 2014 Sep-Oct;20(5):254-9. doi: 10.1016/j.rppneu.2014.04.004. Epub 2014 Jul 18.
10
Autoimmune pulmonary alveolar proteinosis: treatment options in year 2013.自身免疫性肺肺泡蛋白沉积症：2013 年的治疗选择。
Respirology. 2013 Jan;18(1):82-91. doi: 10.1111/j.1440-1843.2012.02274.x.