Preventing Substance Use and Overdose Among Young Adults: The Role of Social Determinants of Health.

The United States is in the midst of an evolving overdose crisis, driven by the proliferation of potent synthetic opioids (e.g., illicitly made fentanyl), the resurgence of stimulants (e.g., methamphetamine), and the introduction of adulterants (e.g., xylazine) into the illicit drug supply. These substance use challenges are happening against the backdrop of rising mental health challenges that are closely linked to substance use and overdose. As overdose deaths have increased, the demographic profile of those dying has shifted and now disproportionately affects certain racial and ethnic minority populations. Social determinants of health (SDOH) are an underexplored component of the prevention response but are particularly salient in addressing substance use and overdose. Many SDOH have been linked to an increased risk for substance use and overdose, either directly or indirectly. The author examines the connection between SDOH and substance use and overdose, with a particular focus on young adults.