婴儿体内原卟啉水平升高与铅负荷的关系

Occurrence of elevated protoporphyrin levels in relation to lead burden in infants.

作者信息

Rabinowitz M B, Leviton A, Needleman H L

出版信息

Environ Res. 1986 Apr;39(2):253-7. doi: 10.1016/s0013-9351(86)80051-2.

Abstract

Simultaneous blood lead (PbB), erythrocyte protoporphyrin (EP), and hematocrit measurements were made semiannually in 232 normal infants from 6 to 24 months of age. The PbB averaged 7 (SD = 5) and ranged from 0 to 64 micrograms/dl. The incidence of elevated EP, a marker for deranged heme synthesis, was unrelated to PbB at levels below 15 micrograms/dl but was fourfold greater among the infants with PbB above 15 micrograms/dl. This relationship persisted even after eliminating the 31 (4%) anemic (hematocrit less than 33%) samples. The confounding effects of iron deficiency are discussed.

摘要

对232名6至24个月大的正常婴儿每半年同时进行一次血铅（PbB）、红细胞原卟啉（EP）和血细胞比容测量。血铅平均为7（标准差 = 5），范围为0至64微克/分升。EP升高是血红素合成紊乱的一个指标，在血铅水平低于15微克/分升时，其发生率与血铅无关，但在血铅高于15微克/分升的婴儿中，其发生率高出四倍。即使剔除了31份（4%）贫血（血细胞比容低于33%）样本后，这种关系仍然存在。文中讨论了缺铁的混杂效应。