Carvalho F M, Silvany-Neto A M, Barbosa A C, Cotrim C R, Tavares T M
Department of Preventive Medicine, Federal University of Bahia, Brazil.
Environ Res. 1995 Oct;71(1):11-5. doi: 10.1006/enrs.1995.1061.
The dose-response relationship between erythrocyte protoporphyrin (EP) and blood lead (PbB) was investigated among children with different subgroups of iron status. The data bank from Santo Amaro City, Brazil, was taken to study 490 children aged 1-9 years who lived at less than 900 m from a primary lead smelter. Mean PbB was 58.9 +/- 25.3 micrograms/dl and mean EP was 87.1 +/- 68.1 micrograms/dl. At PbB levels lower than 60 micrograms/dl, the dose-response curve for EP versus PbB followed the classical pattern; children with low iron status showing greater EP "response" than those with typical iron status and those with high iron status, after controlling for the effects of age and racial group. Among children with PbB > or = 60 micrograms/dl, EP response increased according to the following order: typical < low < high iron status.
在不同铁状态亚组的儿童中，研究了红细胞原卟啉（EP）与血铅（PbB）之间的剂量反应关系。采用巴西圣阿马罗市的数据库，研究了居住在距一家铅冶炼厂不到900米处的490名1至9岁儿童。平均血铅水平为58.9±25.3微克/分升，平均红细胞原卟啉水平为87.1±68.1微克/分升。在血铅水平低于60微克/分升时，红细胞原卟啉与血铅的剂量反应曲线遵循经典模式；在控制年龄和种族组的影响后，铁状态低的儿童比铁状态正常和铁状态高的儿童表现出更大的红细胞原卟啉“反应”。在血铅≥60微克/分升的儿童中，红细胞原卟啉反应按以下顺序增加：正常铁状态＜低铁状态＜高铁状态。
