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本文引用的文献

1
Clinical features, pathophysiology, and management of acute myelopathy following CAR T-cell therapy.CAR T 细胞治疗后急性脊髓病的临床特征、病理生理学和治疗。
Blood. 2024 Nov 14;144(20):2083-2094. doi: 10.1182/blood.2024025679.
2
PD-1 downregulation enhances CAR-T cell antitumor efficiency by preserving a cell memory phenotype and reducing exhaustion.PD-1 下调通过维持细胞记忆表型和减少衰竭来增强 CAR-T 细胞的抗肿瘤效率。
J Immunother Cancer. 2024 Apr 8;12(4):e008429. doi: 10.1136/jitc-2023-008429.
3
Timing of anti-PD-L1 antibody initiation affects efficacy/toxicity of CD19 CAR T-cell therapy for large B-cell lymphoma.抗 PD-L1 抗体起始时机影响 CD19 CAR T 细胞治疗大 B 细胞淋巴瘤的疗效/毒性。
Blood Adv. 2024 Jan 23;8(2):453-467. doi: 10.1182/bloodadvances.2023011287.
4
Three-year follow-up analysis of axicabtagene ciloleucel in relapsed/refractory indolent non-Hodgkin lymphoma (ZUMA-5).ZUMA-5 研究：复发/难治性惰性非霍奇金淋巴瘤中 axicabtagene ciloleucel 的 3 年随访分析。
Blood. 2024 Feb 8;143(6):496-506. doi: 10.1182/blood.2023021243.
5
Case Report: Severe cutaneous adverse event associated with checkpoint inhibition in the setting of CAR T-cell therapy: beyond CRS.病例报告：嵌合抗原受体T细胞疗法背景下与检查点抑制相关的严重皮肤不良事件：超越细胞因子释放综合征
Front Oncol. 2023 Jun 15;13:1171031. doi: 10.3389/fonc.2023.1171031. eCollection 2023.
6
Survival with Axicabtagene Ciloleucel in Large B-Cell Lymphoma.阿基仑赛治疗大 B 细胞淋巴瘤的总生存。
N Engl J Med. 2023 Jul 13;389(2):148-157. doi: 10.1056/NEJMoa2301665. Epub 2023 Jun 5.
7
Efficacy of checkpoint inhibition after CAR-T failure in aggressive B-cell lymphomas: outcomes from 15 US institutions.CAR-T 治疗失败后接受检查点抑制治疗侵袭性 B 细胞淋巴瘤的疗效：来自 15 家美国机构的结果。
Blood Adv. 2023 Aug 22;7(16):4528-4538. doi: 10.1182/bloodadvances.2023010016.
8
Immune priming with avelumab and rituximab prior to R-CHOP in diffuse large B-cell lymphoma: the phase II AvR-CHOP study.avelumab 和利妥昔单抗在 R-CHOP 前对弥漫性大 B 细胞淋巴瘤的免疫启动：Ⅱ期 AvR-CHOP 研究。
Leukemia. 2023 May;37(5):1092-1102. doi: 10.1038/s41375-023-01863-7. Epub 2023 Mar 11.
9
How I treat unique and difficult-to-manage cases of CAR T-cell therapy-associated neurotoxicity.我如何治疗 CAR T 细胞治疗相关神经毒性的独特且难以管理的病例。
Blood. 2023 May 18;141(20):2443-2451. doi: 10.1182/blood.2022017604.
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Five-year follow-up of ZUMA-1 supports the curative potential of axicabtagene ciloleucel in refractory large B-cell lymphoma.ZUMA-1 的 5 年随访结果支持 axi-cel 在难治性大 B 细胞淋巴瘤中的治疗潜力。
Blood. 2023 May 11;141(19):2307-2315. doi: 10.1182/blood.2022018893.

Severe toxicity, but long-term persistence of CAR T cells after immune checkpoint inhibitors in large B-cell lymphoma.

作者信息

Deschênes-Simard Xavier, Pennisi Martina, Perales Miguel-Angel, Shah Gunjan L, Zelenetz Andrew D, Yahalom Joachim, Imber Brandon S, Santomasso Bianca D, Dahi Parastoo B

机构信息

Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Department of Medicine, University of Montreal, Montréal, Quebec, Canada.

出版信息

Leuk Lymphoma. 2025 Mar;66(3):535-540. doi: 10.1080/10428194.2024.2430703. Epub 2024 Nov 20.

DOI:10.1080/10428194.2024.2430703
PMID:39565041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11850207/
Abstract
摘要