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评估从高海拔返回中海拔的大鼠肺动脉压、血液指标和心肌微循环。

Evaluation of pulmonary artery pressure, blood indices, and myocardial microcirculation in rats returning from high altitude to moderate altitude.

机构信息

Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.

Department of Radiology, Jining No.1 People's Hospital, Jining, China.

出版信息

Eur Radiol Exp. 2024 Nov 20;8(1):131. doi: 10.1186/s41747-024-00514-5.

DOI:10.1186/s41747-024-00514-5
PMID:39565546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11579275/
Abstract

BACKGROUND

To investigate changes in pulmonary artery pressure (PAP), blood indices, and myocardial microcirculation in rats returning from high altitude (HA) to moderate altitude (MA).

METHODS

Forty 4-week-old male Sprague-Dawley rats were randomly divided into four groups with ten rats in each group. One group was transported to the MA area (MA-group), and the other three groups were transported to HA (HA-group-A, HA-group-B, and HA-group-C). After 28 weeks of age, the rats from the HA area were transported to the MA area for 0 days, 10 days, and 20 days, respectively. PAP, routine blood tests, and computed tomography myocardial perfusion indices were measured.

RESULTS

Compared with the MA-group, the body weight of HA-groups decreased (p < 0.05), and PAP in HA-group-A and HA-group-B increased (p < 0.05). In the HA groups, PAP initially increased and then decreased. Compared with the MA-group, red blood cells (RBC), hemoglobin (HGB), and hematocrit (HCT) of rats in HA-group-A increased (p < 0.05). Compared with the HA-group-A, RBC, HGB, and HCT of HA-group-B gradually decreased (p < 0.05) while MCV decreased (p < 0.05), and PLT of HA-group-C increased (p < 0.05). Compared with the MA group, blood flow (BF) and blood volume (BV) of the HA-group-A decreased (p < 0.05). Compared with the HA-group-A, TTP increased first and then decreased (p < 0.05), and BF and BV increased gradually (p < 0.05). Pathological results showed that myocardial fiber arrangement was disordered, and cell space widened in the HA group.

CONCLUSION

PAP, blood parameters, and myocardial microcirculation in rats returning from high to MA exhibited significant changes.

RELEVANCE STATEMENT

This study provides an experimental basis for understanding the physiological and pathological mechanisms during the process of deacclimatization to HA and offers new insights for the prevention and treatment of deacclimatization to HA syndrome.

KEY POINTS

Forty rats were raised in a real plateau environment. Myocardial microcirculation was detected by CT myocardial perfusion imaging. The PAP of the unacclimated rats increased first and then decreased. The myocardial microcirculation of the deacclimated rats showed hyperperfusion changes.

摘要

背景

探讨从高海拔（HA）返回中海拔（MA）后肺动脉压（PAP）、血液指标和心肌微循环的变化。

方法

40 只 4 周龄雄性 Sprague-Dawley 大鼠随机分为 4 组，每组 10 只。一组被运送到 MA 地区（MA 组），另外三组被运送到 HA（HA 组-A、HA 组-B 和 HA 组-C）。28 周龄后，HA 地区的大鼠分别被运送到 MA 地区 0、10 和 20 天。测量 PAP、常规血液检查和计算机断层扫描心肌灌注指数。

结果

与 MA 组相比，HA 组的体重下降（p<0.05），HA 组-A 和 HA 组-B 的 PAP 升高（p<0.05）。在 HA 组中，PAP 先升高后降低。与 MA 组相比，HA 组-A 的大鼠红细胞（RBC）、血红蛋白（HGB）和红细胞压积（HCT）升高（p<0.05）。与 HA 组-A 相比，HA 组-B 的 RBC、HGB 和 HCT 逐渐下降（p<0.05），MCV 下降（p<0.05），HA 组-C 的 PLT 升高（p<0.05）。与 MA 组相比，HA 组-A 的血流（BF）和血容量（BV）下降（p<0.05）。与 HA 组-A 相比，TTP 先升高后降低（p<0.05），BF 和 BV 逐渐升高（p<0.05）。病理结果显示，HA 组心肌纤维排列紊乱，细胞间隙增宽。

结论

从高海拔返回中海拔的大鼠的 PAP、血液参数和心肌微循环发生了显著变化。

意义

本研究为了解高海拔脱适应过程中的生理和病理机制提供了实验基础，为高海拔脱适应综合征的防治提供了新的思路。

重点

40 只大鼠在真实高原环境中饲养。通过 CT 心肌灌注成像检测心肌微循环。未适应大鼠的 PAP 先升高后降低。脱适应大鼠的心肌微循环呈高灌注改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc4c/11579275/07f3c5eab6ca/41747_2024_514_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc4c/11579275/b8e51690ca7d/41747_2024_514_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc4c/11579275/4e8b17e3b8f5/41747_2024_514_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc4c/11579275/798f69700ef6/41747_2024_514_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc4c/11579275/dd46918613c1/41747_2024_514_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc4c/11579275/07f3c5eab6ca/41747_2024_514_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc4c/11579275/b8e51690ca7d/41747_2024_514_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc4c/11579275/4e8b17e3b8f5/41747_2024_514_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc4c/11579275/798f69700ef6/41747_2024_514_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc4c/11579275/dd46918613c1/41747_2024_514_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc4c/11579275/07f3c5eab6ca/41747_2024_514_Fig5_HTML.jpg

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