Nuclear Medicine Department, CHR Orleans, 14, Avenue de l'Hôpital, 45100 Orleans, France; UMR 1253, iBrain, Université de Tours, Inserm, 37000 Tours, France.
UMR 1253, iBrain, Université de Tours, Inserm, 37000 Tours, France; Nuclear Medicine Department, CHRU Tours, 37000 Tours, France.
Arch Cardiovasc Dis. 2021 Dec;114(12):818-827. doi: 10.1016/j.acvd.2021.10.006. Epub 2021 Nov 17.
Myocardial flow reserve represents the ratio of myocardial blood flow between stress and rest, giving functional information about both macrocirculation and microcirculation; it has been reported extensively in positron emission tomography, with an increase in diagnostic performance, providing important prognostic information and being a powerful tool to guide therapy. Advances in single photon emission computed tomography, with the widespread availability of "cadmium zinc telluride" single photon emission computed tomography cameras, raise the question of myocardial flow reserve use in daily clinical practice. In this article, we review the pathophysiology of myocardial blood flow and myocardial flow reserve, and the initial data available from single photon emission computed tomography myocardial blood flow and myocardial flow reserve evaluation; we also discuss potential limitations to the wider implementation of flow evaluation in single photon emission computed tomography.
心肌血流储备代表了应激和休息状态下的心肌血流比值，提供了关于大循环和微循环的功能信息；它在正电子发射断层扫描中得到了广泛的报道，其诊断性能有所提高，提供了重要的预后信息，是指导治疗的有力工具。随着“碲化镉锌”单光子发射计算机断层扫描相机的广泛应用，单光子发射计算机断层扫描技术取得了进展，这引发了关于在日常临床实践中使用心肌血流储备的问题。本文综述了心肌血流和心肌血流储备的病理生理学，以及单光子发射计算机断层扫描心肌血流和心肌血流储备评估的初步数据；我们还讨论了在单光子发射计算机断层扫描中更广泛地实施血流评估的潜在局限性。
