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秀丽隐杆线虫中 Smed-foxO 对细胞死亡的调控

Cell Death Regulation by Smed-foxO in the Planarian Schmidtea mediterranea.

机构信息

Department of Genetics, Microbiology and Statistics, Universitat de Barcelona, Barcelona, Catalunya, Spain.

Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain.

出版信息

Methods Mol Biol. 2025;2871:179-191. doi: 10.1007/978-1-0716-4217-7_17.

DOI:10.1007/978-1-0716-4217-7_17
PMID:39565589
Abstract

The planarian Schmidtea mediterranea shows nutrient-dependent whole-body plasticity. Starvation leads to body size reduction, while feeding triggers growth. The balance of cell proliferation and cell death controls cell number, driving organismal body size. Here, we uncovered the role of FoxO in controlling cell death through TUNEL and caspase-3 assays and bak qPCR detection in foxO RNAi planarians.

摘要

扁形动物地中海星虫表现出营养依赖性的全身可塑性。饥饿会导致身体缩小，而进食则会引发生长。细胞增殖和细胞死亡的平衡控制着细胞数量，从而驱动生物体的体型。在这里，我们通过 TUNEL 和 caspase-3 检测以及 foxO RNAi 扁形动物中 bak qPCR 检测，揭示了 FoxO 通过控制细胞死亡在其中的作用。

相似文献

[1]
Cell Death Regulation by Smed-foxO in the Planarian Schmidtea mediterranea.

Methods Mol Biol. 2025

[2]
Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death.

Sci Rep. 2021-2-3

[3]
Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling.

Dis Model Mech. 2008

[4]
The Akt signaling pathway is required for tissue maintenance and regeneration in planarians.

BMC Dev Biol. 2016-4-11

[5]
Sirtuin-1 regulates organismal growth by altering feeding behavior and intestinal morphology in planarians.

J Cell Sci. 2020-5-27

[6]
The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea.

Development. 2010-3-10

[7]
Dynein assembly factor with WD repeat domains 1 (DAW1) is required for the function of motile cilia in the planarian Schmidtea mediterranea.

Dev Growth Differ. 2020-6-1

[8]
Silencing of Smed-betacatenin1 generates radial-like hypercephalized planarians.

Development. 2008-4

[9]
Regeneration and maintenance of the planarian midline is regulated by a slit orthologue.

Dev Biol. 2007-7-15

[10]
Detection of apoptosis during planarian regeneration by the expression of apoptosis-related genes and TUNEL assay.

Gene. 2004-5-26

本文引用的文献

[1]
Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.

Nat Commun. 2023-1-18

[2]
Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases.

Cell Biosci. 2021-11-2

[3]
Analysis of Fox genes in Schmidtea mediterranea reveals new families and a conserved role of Smed-foxO in controlling cell death.

Sci Rep. 2021-2-3

[4]
PlanExp: intuitive integration of complex RNA-seq datasets with planarian omics resources.

Bioinformatics. 2020-3-1

[5]
The Akt signaling pathway is required for tissue maintenance and regeneration in planarians.

BMC Dev Biol. 2016-4-11

[6]
JNK controls the onset of mitosis in planarian stem cells and triggers apoptotic cell death required for regeneration and remodeling.

PLoS Genet. 2014-6-12

[7]
TORC1 is required to balance cell proliferation and cell death in planarians.

Dev Biol. 2012-3-16

[8]
Cell death and tissue remodeling in planarian regeneration.

Dev Biol. 2009-9-18

[9]
Bcl-2 family members: dual regulators of apoptosis and autophagy.

Autophagy. 2008-7

[10]
Bromodeoxyuridine specifically labels the regenerative stem cells of planarians.

Dev Biol. 2000-4-15

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