秀丽隐杆线虫中 Smed-foxO 对细胞死亡的调控
Cell Death Regulation by Smed-foxO in the Planarian Schmidtea mediterranea.
机构信息
Department of Genetics, Microbiology and Statistics, Universitat de Barcelona, Barcelona, Catalunya, Spain.
Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Barcelona, Spain.
出版信息
Methods Mol Biol. 2025;2871:179-191. doi: 10.1007/978-1-0716-4217-7_17.
The planarian Schmidtea mediterranea shows nutrient-dependent whole-body plasticity. Starvation leads to body size reduction, while feeding triggers growth. The balance of cell proliferation and cell death controls cell number, driving organismal body size. Here, we uncovered the role of FoxO in controlling cell death through TUNEL and caspase-3 assays and bak qPCR detection in foxO RNAi planarians.
扁形动物地中海星虫表现出营养依赖性的全身可塑性。饥饿会导致身体缩小，而进食则会引发生长。细胞增殖和细胞死亡的平衡控制着细胞数量，从而驱动生物体的体型。在这里，我们通过 TUNEL 和 caspase-3 检测以及 foxO RNAi 扁形动物中 bak qPCR 检测，揭示了 FoxO 通过控制细胞死亡在其中的作用。
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