Du Shuqi, Zheng Hui
Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.
Cell Biosci. 2021 Nov 2;11(1):188. doi: 10.1186/s13578-021-00700-7.
Aging happens to all of us as we live. Thanks to the improved living standard and discovery of life-saving medicines, our life expectancy has increased substantially across the world in the past century. However, the rise in lifespan leads to unprecedented increases in both the number and the percentage of individuals 65 years and older, accompanied by the increased incidences of age-related diseases such as type 2 diabetes mellitus and Alzheimer's disease. FoxO transcription factors are evolutionarily conserved molecules that play critical roles in diverse biological processes, in particular aging and metabolism. Their dysfunction is often found in the pathogenesis of many age-related diseases. Here, we summarize the signaling pathways and cellular functions of FoxO proteins. We also review the complex role of FoxO in aging and age-related diseases, with focus on type 2 diabetes and Alzheimer's disease and discuss the possibility of FoxO as a molecular link between aging and disease risks.
随着我们的生活，衰老会降临到我们每个人身上。由于生活水平的提高和救命药物的发现，在过去的一个世纪里，全世界的预期寿命都大幅提高。然而，寿命的延长导致65岁及以上人群的数量和比例都出现了前所未有的增长，同时与年龄相关的疾病如2型糖尿病和阿尔茨海默病的发病率也有所增加。FoxO转录因子是进化上保守的分子，在多种生物学过程中发挥关键作用，尤其是在衰老和代谢方面。它们的功能障碍常常出现在许多与年龄相关疾病的发病机制中。在这里，我们总结了FoxO蛋白的信号通路和细胞功能。我们还回顾了FoxO在衰老和与年龄相关疾病中的复杂作用，重点关注2型糖尿病和阿尔茨海默病，并讨论了FoxO作为衰老与疾病风险之间分子联系的可能性。
