Assistant Dean for Research, University of Puerto Rico, School of Dental Medicine, San Juan, Puerto Rico; Principal Investigator, Dental Research Associates, Inc., San Juan, Puerto Rico.
President, LRM Statistical Consulting LLC, West Orange, New Jersey.
Compend Contin Educ Dent. 2024 Nov-Dec;45(Suppl 3):46-52.
This study compared the extrinsic tooth stain removal efficacy of a 0.454% stannous fluoride dentifrice stabilized with nitrate and phosphates (SNaP) versus a non-whitening regular fluoride dentifrice (negative control) after 3 and 6 weeks of product use.
This phase III, double-blind, randomized, two-cell, parallel-group study was conducted on 80 healthy adults in Puerto Rico. After a baseline tooth stain assessment and oral examinations, study participants were randomly assigned to either the SNaP (test) group or a negative control group. Participants brushed their teeth twice daily for 2 minutes for the 6-week duration. The efficacy for extrinsic tooth stain removal was assessed via Lobene composite stain index, stain area index, and stain intensity index scores for each treatment group at baseline, 3 weeks, and 6 weeks.
Seventy-eight participants completed the 6-week study. The SNaP dentifrice provided more stain removal relative to baseline tooth stain scores (3-week: 24.4%; 6-week: 35.6%; P less than .001) and more stain removal relative to the regular fluoride dentifrice (3-week: 24.3%; 6-week: 39.1%; P less than .001).
The results indicate that the SNaP toothpaste provides a greater level of efficacy in the removal of extrinsic tooth stain as compared to a regular fluoride toothpaste when used twice a day, as measured with Lobene stain index at 3 weeks and 6 weeks.
A new stannous fluoride dentifrice stabilized with nitrate and phosphates offers greater efficacy in removing extrinsic tooth stain as compared to regular fluoride toothpaste.
本研究比较了一种含有硝酸根和磷酸盐稳定的 0.454% 氟化亚锡牙膏（SNaP）与不含增白剂的普通含氟牙膏（阴性对照）在使用产品 3 周和 6 周后的外源性牙齿着色去除效果。
本项 III 期、双盲、随机、两细胞、平行组研究在波多黎各的 80 名健康成年人中进行。在基线牙齿着色评估和口腔检查后，研究参与者被随机分配到 SNaP（试验）组或阴性对照组。参与者在 6 周内每天刷牙两次，每次 2 分钟。使用 Lobene 综合染色指数、染色面积指数和染色强度指数分别评估每个治疗组在基线、3 周和 6 周时的外源性牙齿染色去除效果。
78 名参与者完成了 6 周的研究。SNaP 牙膏相对于基线牙齿染色评分（3 周：24.4%；6 周：35.6%；P<0.001）和普通含氟牙膏（3 周：24.3%；6 周：39.1%；P<0.001）提供了更多的牙齿染色去除效果。
结果表明，与普通含氟牙膏相比，SNaP 牙膏在每日使用两次时，使用 3 周和 6 周后，用 Lobene 染色指数测量，在外源性牙齿染色去除方面具有更高的疗效。
一种含有硝酸根和磷酸盐稳定的新的氟化亚锡牙膏在去除外源性牙齿着色方面比普通含氟牙膏更有效。
