Wang Yuxin, Jiang Zhiqi, Chu Chunguang, Zhang Zhen, Wang Jiang, Li Dianyou, He Naying, Fietkiewicz Chris, Zhou Changsong, Kaiser Marcus, Bai Xuze, Zhang Chencheng, Liu Chen
School of Electrical and Information Engineering, Tianjin University, Tianjin, China.
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
NPJ Parkinsons Dis. 2024 Nov 20;10(1):224. doi: 10.1038/s41531-024-00835-7.
Deep brain stimulation (DBS) can ameliorate motor symptoms in Parkinson's disease (PD), but its mechanism remains unclear. This work constructs a multi-scale brain model using the fMRI data from 27 PD patients with subthalamic DBS and 30 healthy controls. The model fits microscopic coupling parameters in the cortico-basal ganglia-thalamic neural loop to match individual connectivity, finding the "push-pull" effect of basal ganglia network. Specifically, increased GABAergic projection into the thalamus from basal ganglia worsens rigidity, while reduced GABAergic projection within the cortex exacerbates bradykinesia, suggesting that the dopamine deficiency induces the chain coupling variations to "push" the network to an abnormal state. Conversely, DBS can alleviate rigidity by enhancing GABAergic projections within the basal ganglia, and improve bradykinesia by reducing cortical projections to basal ganglia, exhibiting that DBS "pulls" the network to a healthy state. This work combines the microscopic and macroscopic neural information for understanding PD and its treatment.
深部脑刺激（DBS）可改善帕金森病（PD）的运动症状，但其机制尚不清楚。这项研究利用27名接受丘脑底核DBS治疗的PD患者和30名健康对照者的功能磁共振成像（fMRI）数据构建了一个多尺度脑模型。该模型拟合皮质-基底神经节-丘脑神经回路中的微观耦合参数以匹配个体连接性，发现了基底神经节网络的“推-拉”效应。具体而言，基底神经节向丘脑的γ-氨基丁酸能投射增加会加重僵硬，而皮质内γ-氨基丁酸能投射减少会加剧运动迟缓，这表明多巴胺缺乏会导致连锁耦合变化，将网络“推”向异常状态。相反，DBS可通过增强基底神经节内的γ-氨基丁酸能投射来缓解僵硬，并通过减少皮质向基底神经节的投射来改善运动迟缓，表明DBS将网络“拉”向健康状态。这项研究结合了微观和宏观神经信息来理解PD及其治疗方法。
