Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran.
ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, 1517964311, Tehran, Iran.
Diagn Pathol. 2024 Nov 20;19(1):148. doi: 10.1186/s13000-024-01574-2.
Cancer diagnostic probe (CDP) as a newly entered tool in real-time breast cavity margin evaluation showed great improvement in smart margin shaving intra-operatively. This system increased the rate of involved margin detection to 30% with respect to frozen section. In this study for the first time we showed the independent role of CDP in finding the involved cavity side margins which were not diagnosed by permananet pathology of their tumor side interface. Among 147 detected margins by CDP, 23 lesions with invasive component and ductal carcinoma in-situ/ductal cancerization weren't reported as involved margins in permanent pathology of tumor side. Our gold standard was the histology of cavity margin specimen had been scored as involved lesion by CDP. It seems that even when the permanent pathology of surgical margins is used for final declaration, role of CDP is irreplaceable. This distinguished achievement has been obtained intra-operatively in real-time by CDP while involved report in permanent pathology of tumor margins induce re-surgery for the patient.
癌症诊断探针（CDP）作为一种新进入的实时乳腺腔缘评估工具，在术中智能切缘方面显示出了很大的改进。与冷冻切片相比，该系统将受累切缘的检出率提高到了 30%。在这项研究中，我们首次表明，CDP 在发现永久性肿瘤侧界面病理检查未诊断的受累腔侧边缘方面具有独立作用。在 CDP 检测到的 147 个边缘中，23 个浸润性成分和原位癌/导管癌化的病变在肿瘤侧的永久性病理检查中未报告为受累边缘。我们的金标准是腔缘标本的组织学已被 CDP 评分诊断为受累病变。即使在使用外科切缘的永久性病理检查作为最终报告时，CDP 的作用也是不可替代的。这一显著的成就通过 CDP 在术中实时获得，而在永久性肿瘤切缘病理检查中报告的受累边缘则需要为患者进行再次手术。
