一种用于诊断2型糖尿病的新型指标：胆固醇、高密度脂蛋白和血糖（CHG）指数。
A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index.
作者信息
Mansoori Amin, Nosrati Mina, Dorchin Mohsen, Mohammadyari Fatemeh, Derakhshan-Nezhad Elahe, Ferns Gordon, Esmaily Habibollah, Ghayour-Mobarhan Majid
机构信息
Department of Applied Mathematics, Ferdowsi University of Mashhad, Mashhad, Iran.
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
J Diabetes Investig. 2025 Feb;16(2):309-314. doi: 10.1111/jdi.14343. Epub 2024 Nov 21.
BACKGROUND
Gold standard methods of type 2 diabetes mellitus are expensive and therefore not practical for large scale studies in low-income countries. We have investigated the total cholesterol, high density lipoprotein (HDL), and glucose (CHG) index for diagnosis of type 2 diabetes mellitus index which is derived from fasting state. In this study we aimed to compare the accuracy of with CHG index and triglycerides (TG) and glucose levels (TyG) as surrogates of type 2 diabetes mellitus.
METHODS
A total of 9,704 individuals between 35 and 65 years of age were recruited as part of the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study. They were categorized into two groups, those with and without type 2 diabetes mellitus. The cut-off in groups to detection of type 2 diabetes mellitus was fasting blood glucose ≥126 mg/dL in blood sample. Receiver operating characteristic (ROC) curve analysis was used to establish the cut-off of indices to evaluate the sensitivity and specificity of them.
RESULTS
The best cut-off of CHG index for diagnosis of type 2 diabetes mellitus was 5.57 which was associated with a sensitivity of 70.38% and specificity of 89.82% values. This was in comparison to the TyG index. LR+ CHG index was 6.91 compared to 3.47 for the TyG index and the AUC of CHG index was 0.864 (0.857, 0.871) compared with 0.825 (0.818, 0.833) for the TyG index. This indicates that the CHG index has a higher efficiency value to diagnose of type 2 diabetes mellitus.
CONCLUSIONS
The CHG index could be useful for the detection of type 2 diabetes mellitus.
背景
2型糖尿病的金标准检测方法成本高昂，因此对于低收入国家的大规模研究而言并不实用。我们研究了用于诊断源自空腹状态的2型糖尿病指数的总胆固醇、高密度脂蛋白（HDL）和葡萄糖（CHG）指数。在本研究中，我们旨在比较CHG指数与甘油三酯（TG）和血糖水平（TyG）作为2型糖尿病替代指标的准确性。
方法
作为马什哈德中风和心脏动脉粥样硬化疾病（MASHAD）研究的一部分，共招募了9704名年龄在35至65岁之间的个体。他们被分为两组，即患有和未患有2型糖尿病的个体。两组中2型糖尿病的检测临界值为血样中空腹血糖≥126mg/dL。采用受试者工作特征（ROC）曲线分析来确定各指数的临界值，以评估其敏感性和特异性。
结果
CHG指数诊断2型糖尿病的最佳临界值为5.57，其敏感性为70.38%，特异性为89.82%。这是与TyG指数相比较的结果。CHG指数的阳性似然比为6.91，而TyG指数为3.47；CHG指数的曲线下面积（AUC）为0.864（0.857，0.871），而TyG指数为0.825（0.818，0.833）。这表明CHG指数在诊断2型糖尿病方面具有更高的效能值。
结论
CHG指数可能有助于2型糖尿病的检测。
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