Polyphenols in Human Nutrition: European Regulations and Potential Classification as a Novel Food or Food Additive.

Polyphenols are widely present in botanicals and are partially responsible for the health benefits associated with plant-based diets. Due to their nutritional and health-promoting properties, polyphenols are increasingly being proposed as innovative food ingredients, whether for technological applications or for inclusion in food supplements and other food products to enhance health. However, the regulatory considerations surrounding the use of polyphenols in human nutrition are critical. Although polyphenols are routinely consumed through fruits and vegetables, in Europe, polyphenols and plant extracts can be classified as novel foods or food additives. The scientific evaluation conducted by the European Food Safety Authority (EFSA) to obtain the necessary authorizations is stringent, requiring a substantial level of evidence to ensure the safe use of polyphenols. This work aims to provide an overview of the current European regulatory frameworks for novel foods and food additives and to discuss the scientific requirements for the approval of pure polyphenols and polyphenol-rich botanical extracts in Europe.