TNF 表达的 CD1d+单核细胞与恰加斯心肌病患者中 CD4-CD8-T 细胞的激活有关。
TNF-expressing CD1d+ monocytes are associated with the activation of CD4- CD8- T cells in patients with Chagas cardiomyopathy.
机构信息
Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Belo Horizonte, MG, Brasil.
Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Salvador, BA, Brasil.
出版信息
Rev Soc Bras Med Trop. 2024 Nov 15;57. doi: 10.1590/0037-8682-0181-2024. eCollection 2024.
BACKGROUND
Chagas disease cardiomyopathy is characterized by intense immune activation, with double-negative (DN) T cells as key producers of inflammatory cytokines. CD1d is an antigen-presenting molecule involved in the activation of DN T cells.
METHODS
We characterized CD1d+ monocytes from patients with cardiac (CARD) and indeterminate (IND) disease using flow cytometry.
RESULTS
CARD CD1d+ monocytes exhibited higher expression of TNF, TNF-receptor, PDL-1, and Fas-L compared to those from IND. These monocytes correlated with TNF expression by DN T-cells in CARD but not in IND.
CONCLUSIONS
CD1d+ monocytes from CARD are inflammatory and associated with DN T-cell activation, confirming that CD1d is a target for modulating inflammation in Chagas cardiomyopathy.
背景
恰加斯病心肌病的特征是强烈的免疫激活，双阴性（DN）T 细胞是炎症细胞因子的主要产生者。CD1d 是一种参与 DN T 细胞激活的抗原呈递分子。
方法
我们使用流式细胞术对患有心脏（CARD）和不确定（IND）疾病的患者的 CD1d+单核细胞进行了表征。
结果
与 IND 相比，CARD CD1d+单核细胞表现出更高的 TNF、TNF 受体、PDL-1 和 Fas-L 表达。这些单核细胞与 CARD 而非 IND 中的 DN T 细胞的 TNF 表达相关。
结论
CARD 中的 CD1d+单核细胞具有炎症性，并与 DN T 细胞的激活相关，这证实了 CD1d 是恰加斯心肌病中调节炎症的靶点。
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