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TNF 表达的 CD1d+单核细胞与恰加斯心肌病患者中 CD4-CD8-T 细胞的激活有关。

TNF-expressing CD1d+ monocytes are associated with the activation of CD4- CD8- T cells in patients with Chagas cardiomyopathy.

机构信息

Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Belo Horizonte, MG, Brasil.

Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Salvador, BA, Brasil.

出版信息

Rev Soc Bras Med Trop. 2024 Nov 15;57. doi: 10.1590/0037-8682-0181-2024. eCollection 2024.

DOI:10.1590/0037-8682-0181-2024
PMID:39570155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11654746/
Abstract

BACKGROUND

Chagas disease cardiomyopathy is characterized by intense immune activation, with double-negative (DN) T cells as key producers of inflammatory cytokines. CD1d is an antigen-presenting molecule involved in the activation of DN T cells.

METHODS

We characterized CD1d+ monocytes from patients with cardiac (CARD) and indeterminate (IND) disease using flow cytometry.

RESULTS

CARD CD1d+ monocytes exhibited higher expression of TNF, TNF-receptor, PDL-1, and Fas-L compared to those from IND. These monocytes correlated with TNF expression by DN T-cells in CARD but not in IND.

CONCLUSIONS

CD1d+ monocytes from CARD are inflammatory and associated with DN T-cell activation, confirming that CD1d is a target for modulating inflammation in Chagas cardiomyopathy.

摘要

背景

恰加斯病心肌病的特征是强烈的免疫激活，双阴性（DN）T 细胞是炎症细胞因子的主要产生者。CD1d 是一种参与 DN T 细胞激活的抗原呈递分子。

方法

我们使用流式细胞术对患有心脏（CARD）和不确定（IND）疾病的患者的 CD1d+单核细胞进行了表征。

结果

与 IND 相比，CARD CD1d+单核细胞表现出更高的 TNF、TNF 受体、PDL-1 和 Fas-L 表达。这些单核细胞与 CARD 而非 IND 中的 DN T 细胞的 TNF 表达相关。

结论

CARD 中的 CD1d+单核细胞具有炎症性，并与 DN T 细胞的激活相关，这证实了 CD1d 是恰加斯心肌病中调节炎症的靶点。

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本文引用的文献

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Clin Immunol. 2023 Jun;251:109331. doi: 10.1016/j.clim.2023.109331. Epub 2023 Apr 23.
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Cytokine Networks as Targets for Preventing and Controlling Chagas Heart Disease.细胞因子网络作为预防和控制恰加斯心脏病的靶点。
Pathogens. 2023 Jan 21;12(2):171. doi: 10.3390/pathogens12020171.
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Double-negative T cells: Setting the stage for disease control or progression.
双阴性 T 细胞：控制疾病或进展的关键。
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Distinct CD4CD8 (Double-Negative) Memory T-Cell Subpopulations Are Associated With Indeterminate and Cardiac Clinical Forms of Chagas Disease.不同的 CD4CD8（双阴性）记忆 T 细胞亚群与恰加斯病的不确定和心脏临床形式有关。
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PD1 and PDL1 molecules control suppressor activity of regulatory T cells in chronic Chagas cardiomyopathy patients.PD1 和 PDL1 分子控制慢性恰加斯心肌病患者调节性 T 细胞的抑制活性。
Hum Immunol. 2019 Jul;80(7):517-522. doi: 10.1016/j.humimm.2019.03.009. Epub 2019 Mar 7.
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Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association.恰加斯心肌病：当前临床知识和管理的更新：美国心脏协会的科学声明。
Circulation. 2018 Sep 18;138(12):e169-e209. doi: 10.1161/CIR.0000000000000599.
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CD86 Expression by Monocytes Influences an Immunomodulatory Profile in Asymptomatic Patients with Chronic Chagas Disease.单核细胞 CD86 的表达影响无症状慢性恰加斯病患者的免疫调节谱。
Front Immunol. 2018 Mar 12;9:454. doi: 10.3389/fimmu.2018.00454. eCollection 2018.
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