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Is This a Causal Relationship? Mendelian Randomization as a Statistical Method for Unraveling Connections.

作者信息

Pires Lucas Vieira Lacerda

机构信息

Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP - Brasil.

出版信息

Arq Bras Cardiol. 2024 Nov 15;121(10):e20240606. doi: 10.36660/abc.20240606. eCollection 2024.

DOI:10.36660/abc.20240606
PMID:39570163
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11634222/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed72/11634222/f08399a6d2ba/0066-782X-abc-121-10-e20240606-gf01-en.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed72/11634222/0263b9520674/0066-782X-abc-121-10-e20240606-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed72/11634222/f08399a6d2ba/0066-782X-abc-121-10-e20240606-gf01-en.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed72/11634222/0263b9520674/0066-782X-abc-121-10-e20240606-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed72/11634222/f08399a6d2ba/0066-782X-abc-121-10-e20240606-gf01-en.jpg

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本文引用的文献

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Arq Bras Cardiol. 2024 Oct 28;121(10):e20230796. doi: 10.36660/abc.20230796. eCollection 2024.
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A Guide to Understanding Mendelian Randomization Studies.孟德尔随机化研究指南。
Arthritis Care Res (Hoboken). 2024 Nov;76(11):1451-1460. doi: 10.1002/acr.25400. Epub 2024 Aug 7.
3
Mendelian randomization for cardiovascular diseases: principles and applications.孟德尔随机化在心血管疾病中的应用：原理与方法。
Eur Heart J. 2023 Dec 14;44(47):4913-4924. doi: 10.1093/eurheartj/ehad736.
4
Mendelian randomization in hepatology: A review of principles, opportunities, and challenges.肝脏病学中的孟德尔随机化：原理、机遇与挑战综述
Hepatology. 2025 Jun 1;81(6):1836-1846. doi: 10.1097/HEP.0000000000000649. Epub 2023 Oct 24.
5
Mendelian randomization for nephrologists.孟德尔随机化：肾科医生的新工具。
Kidney Int. 2023 Dec;104(6):1113-1123. doi: 10.1016/j.kint.2023.09.016. Epub 2023 Sep 30.
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Using genetic association data to guide drug discovery and development: Review of methods and applications.利用遗传关联数据指导药物发现和开发：方法和应用综述。
Am J Hum Genet. 2023 Feb 2;110(2):195-214. doi: 10.1016/j.ajhg.2022.12.017.
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Robust Mendelian randomization in the presence of residual population stratification, batch effects and horizontal pleiotropy.存在残余群体分层、批次效应和水平 pleiotropy 时的稳健孟德尔随机化。
Nat Commun. 2022 Mar 1;13(1):1093. doi: 10.1038/s41467-022-28553-9.
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Reporting methodological issues of the mendelian randomization studies in health and medical research: a systematic review.系统评价健康与医学研究中孟德尔随机化研究方法学问题的报告。
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