看电视时间与心血管疾病的因果关系及潜在机制。
Causal Relationship between Television Viewing Time, Cardiovascular Diseases, and Potential Mechanisms.
机构信息
Xuanwu Hospital, Capital Medical University, Beijing - China.
Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, Beijing - China.
出版信息
Arq Bras Cardiol. 2024 Oct 28;121(10):e20230796. doi: 10.36660/abc.20230796. eCollection 2024.
BACKGROUND
As the predominant leisure-time sedentary behavior, television viewing was documented to increase cardiovascular diseases in observational studies, yet the causal relationship and potential mechanisms remain to be determined.
OBJECTIVES
To systematically investigate the causal relationship between television viewing time, cardiovascular diseases, and potential mechanisms.
METHODS
We conducted a two-sample Mendelian randomization (MR) analysis to estimate causal associations with cardiovascular diseases and biomarkers of cardiometabolic risk. The random inverse-variance weighted method was used as the primary estimate. To account for multiple comparisons, a Bonferroni correction p value for cardiovascular diseases and biomarkers of cardiometabolic risk was 0.0045 and 0.0024, respectively.
RESULTS
Genetically instrumented television viewing time was associated with higher risks of type 2 diabetes (odd ratio [OR]=2.51; 95% confidence interval [CI]: 1.89-3.33; p<0.00001), hypertension (OR=2.11; 95% CI: 1.67-2.66; p<0.00001), coronary heart disease (OR=1.53; 95% CI: 1.23-1.91; p=0.00015), and heart failure (OR=1.42; 95% CI: 1.18-1.70; p=0.00017). Suggestive evidence of harmful associations was also observed for peripheral artery disease (OR=1.58; 95% CI: 1.07-2.34; p=0.02253) and ischemic stroke (OR=1.34; 95% CI: 1.10-1.63; p=0.00328). Biomarkers of cardiometabolic risk, including interleukin 10, leptin, visceral adipose, abdominal subcutaneous adipose, liver fat, body mass index, waist circumference, triglycerides, and C-reactive protein, were increased. Systolic blood pressure, heart rate, low-density lipoprotein, and total cholesterol were potentially increased while high-density lipoprotein was decreased. However, television viewing time had no effect on venous thromboembolism or pulmonary embolism.
CONCLUSION
Television viewing time was causally associated with increased risks of cardiovascular diseases, which may be explained by metabolic and inflammatory mechanisms.
BACKGROUND
An overview of the effect of television viewing time on cardiovascular diseases and biomarkers of cardiometabolic risk.
背景
作为主要的闲暇时间久坐行为，看电视被观察性研究证明会增加心血管疾病，但因果关系和潜在机制仍有待确定。
目的
系统研究看电视时间与心血管疾病和潜在机制之间的因果关系。
方法
我们进行了两样本孟德尔随机化（MR）分析，以估计与心血管疾病和心血管代谢风险生物标志物的因果关联。随机逆方差加权法被用作主要估计方法。为了考虑多次比较，心血管疾病和心血管代谢风险生物标志物的 Bonferroni 校正 p 值分别为 0.0045 和 0.0024。
结果
遗传上与看电视时间相关联与 2 型糖尿病（比值比 [OR]=2.51；95%置信区间 [CI]：1.89-3.33；p<0.00001）、高血压（OR=2.11；95%CI：1.67-2.66；p<0.00001）、冠心病（OR=1.53；95%CI：1.23-1.91；p=0.00015）和心力衰竭（OR=1.42；95%CI：1.18-1.70；p=0.00017）的风险增加相关。外周动脉疾病（OR=1.58；95%CI：1.07-2.34；p=0.02253）和缺血性中风（OR=1.34；95%CI：1.10-1.63；p=0.00328）也观察到有害关联的迹象。心血管代谢风险的生物标志物，包括白细胞介素 10、瘦素、内脏脂肪、腹部皮下脂肪、肝脏脂肪、体重指数、腰围、甘油三酯和 C 反应蛋白，增加。收缩压、心率、低密度脂蛋白和总胆固醇可能增加，而高密度脂蛋白降低。然而，看电视时间对静脉血栓栓塞或肺栓塞没有影响。
结论
看电视时间与心血管疾病风险增加有因果关系，这可能是通过代谢和炎症机制来解释的。
概述
看电视时间对心血管疾病和心血管代谢风险生物标志物影响的综述。
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