Mukherjee Upasana, Sehar Ujala, Brownell Malcolm, Reddy P Hemachandra
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Department of Nutritional Sciences, College Human Sciences, Texas Tech University, Lubbock, TX 79415, USA.
Aging (Albany NY). 2024 Nov 20;16(21):13409-13429. doi: 10.18632/aging.206157.
Sleep disturbances are a significant concern in individuals with dementia, affecting their overall health and quality of life, as well as that of their family members and caregivers. Dementia, a progressive neurodegenerative condition marked by cognitive decline, often coexists with various comorbidities such as cardiovascular disease, diabetes, obesity, anxiety/depression and thyroid disorders. These comorbidities can further impair cognitive function and complicate the clinical management of dementia, making it essential to address them in a holistic manner. This review critically examines the complex interplay between dementia and its associated comorbidities, with a special focus on the prevalence and impact of sleep disturbances. Sleep problems in dementia patients are not only common but also contribute to a faster progression of cognitive decline and increased burden on caregivers. The article explores the mechanisms by which these comorbidities, including cardiovascular conditions and metabolic disorders, exacerbate sleep disturbances and cognitive impairment in dementia patients. By synthesizing recent research findings, the review highlights the importance of identifying and managing modifiable risk factors for sleep disturbances in dementia. Integrated treatment approaches that address both cognitive and sleep-related challenges are essential for improving patient outcomes. The review also underscores the need for further research to develop targeted interventions that can effectively manage sleep disturbances in dementia, thereby enhancing the quality of life for both patients and caregivers. Understanding the relationship between dementia, comorbidities, and sleep disturbances is crucial for the development of comprehensive care strategies. This review aims to inform healthcare professionals about the current state of knowledge and encourage the implementation of evidence-based practices in dementia care.
睡眠障碍是痴呆症患者的一个重要问题，影响着他们的整体健康和生活质量，以及他们的家庭成员和照顾者的生活质量。痴呆症是一种以认知能力下降为特征的进行性神经退行性疾病，常与各种合并症共存，如心血管疾病、糖尿病、肥胖症、焦虑/抑郁症和甲状腺疾病。这些合并症会进一步损害认知功能，使痴呆症的临床管理复杂化，因此必须以整体方式加以解决。本综述批判性地审视了痴呆症与其相关合并症之间的复杂相互作用，特别关注睡眠障碍的患病率和影响。痴呆症患者的睡眠问题不仅常见，而且会导致认知能力下降更快，加重照顾者的负担。本文探讨了包括心血管疾病和代谢紊乱在内的这些合并症加剧痴呆症患者睡眠障碍和认知障碍的机制。通过综合近期的研究结果，本综述强调了识别和管理痴呆症患者睡眠障碍可改变风险因素的重要性。应对认知和睡眠相关挑战的综合治疗方法对于改善患者预后至关重要。本综述还强调需要进一步研究，以制定能够有效管理痴呆症患者睡眠障碍的针对性干预措施，从而提高患者和照顾者的生活质量。了解痴呆症、合并症和睡眠障碍之间的关系对于制定全面的护理策略至关重要。本综述旨在向医疗保健专业人员介绍当前的知识状况，并鼓励在痴呆症护理中实施循证实践。
