Qu Yaning, Xu Mengyue, Yuan Fahu, Zhang Hongxing, Li Hui, Guo Rui, Yu Jinyi, Ren Qinai, Wang Runkui, Wang Peng, Wang Hongbo
School of Life Sciences, Jianghan University, Wuhan 430056, China; Innovation Center for Comprehensive Utilization of Food and Medicine Homologous Specialty Resources, Wuhan 430056, China.
School of Life Sciences, Jianghan University, Wuhan 430056, China; Hubei Province Engineering Research Center for Legume Plants, Wuhan 430056, Hubei, China.
Int J Biol Macromol. 2024 Dec;283(Pt 3):137825. doi: 10.1016/j.ijbiomac.2024.137825. Epub 2024 Nov 19.
Type 2 diabetes poses significant health issues worldwide; however, relatively few effective treatment strategies are currently available. This research seeks to explore the potential hypoglycemic impact of compounds derived from common bean (Phaseolus vulgaris L.) by structurally characterizing a new type of heteropolysaccharide (CIE2-F) and evaluating its hypoglycemic effects in a murine model. CIE2-F primarily comprises 10 monosaccharides, Mw: 9.25 × 10 Da. The polysaccharide exhibited significant anti-obesity effects, alleviated pathological liver damage, and reduced hyperglycemia. In addition, the polysaccharide mitigated insulin resistance and regulated dyslipidemia by increasing serum HDL-C and reducing LDL-C, total cholesterol, and triglycerides in diabetic mice. Furthermore, 16S rRNA sequencing revealed that CIE2-F enriched beneficial gut microbiota, including Akkermansia and Verrucomicrobia, while decreasing pathogenic bacteria.
2型糖尿病在全球范围内引发了重大的健康问题；然而，目前有效的治疗策略相对较少。本研究旨在通过对一种新型杂多糖（CIE2-F）进行结构表征，并在小鼠模型中评估其降血糖作用，探索菜豆（Phaseolus vulgaris L.）衍生化合物的潜在降血糖影响。CIE2-F主要由10种单糖组成，分子量为9.25×10 Da。该多糖具有显著的抗肥胖作用，减轻了肝脏病理损伤，并降低了高血糖。此外，该多糖通过增加糖尿病小鼠血清高密度脂蛋白胆固醇（HDL-C）并降低低密度脂蛋白胆固醇（LDL-C）、总胆固醇和甘油三酯，减轻了胰岛素抵抗并调节了血脂异常。此外，16S rRNA测序显示，CIE2-F富集了有益的肠道微生物群，包括阿克曼氏菌和疣微菌，同时减少了病原菌。
