Stanczak Michal A, Pearce Erika L
Department of Oncology, Johns Hopkins University School of Medicine, Bloomberg-Kimmel Institute of Cancer Immunotherapy, Sydney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Bloomberg-Kimmel Institute of Cancer Immunotherapy, Sydney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA; Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Trends Immunol. 2024 Dec;45(12):920-921. doi: 10.1016/j.it.2024.11.005. Epub 2024 Nov 20.
Tissue-resident memory (T) T cells not only control infection and cancer, but also contribute to inflammatory disease. In a recent study, Obers et al. demonstrate that retinoic acid (RA) and TGF-β direct T residency in mice, with RA uniquely retaining cells in the intestine by limiting migration. This discovery highlights the potential for harnessing local residency cues to enhance tissue-specific T responses.
组织驻留记忆T细胞不仅能控制感染和癌症，还会引发炎症性疾病。在最近的一项研究中，奥伯斯等人证明，视黄酸（RA）和转化生长因子-β（TGF-β）可引导小鼠体内的T细胞驻留，其中RA通过限制迁移将细胞独特地保留在肠道中。这一发现凸显了利用局部驻留信号增强组织特异性T细胞反应的潜力。
