Lorca Luz Alejandra, Ribeiro Ivana Leao, Pizarro Marta, Rebolledo Rebolledo Gonzalo
Hospital del Salvador, Servicio de Salud Metropolitano Oriente, 7500787, Santiago de Chile, Chile.
Faculty of Health Sciences, Catholic University of Maule, 3460000, Talca, Chile.
Support Care Cancer. 2024 Nov 22;32(12):814. doi: 10.1007/s00520-024-09010-3.
To describe the prevalence of fatigue in adults with colorectal cancer (CRC). Additionally, to explore the associations and correlations between fatigue and sociodemographic and clinical characteristics.
Patients with CRC at various phases of the disease were evaluated for fatigue using the Brief Fatigue Inventory (BFI), independence in activities of daily living using the Barthel index, perception of pain using the Visual Analogue Scale (VAS), and performance status using the Eastern Cooperative Oncology Group criteria in a Chilean public hospital. Descriptive analyses were used to describe the variables. Chi-square and Spearman tests were utilized to evaluate associations between fatigue and other variables.
Among 241 patients participate (mean age 68.9 ± 12.2 years) and colon cancer was most common (66.4%). Fatigue was present in all disease phases, with moderate fatigue most prevalent (49.3%), followed by mild (24.2%) and severe (13.6%). Newly diagnosed patients had a higher proportion of severe fatigue (p = 0.04). Women experienced more moderate fatigue than men (p < 0.05). Patients with over three comorbidities and severe pain had higher severe fatigue (p < 0.05). Mood disorders were linked to more severe fatigue, while their absence was related to milder fatigue (p = 0.02). Musculoskeletal disorders correlated with moderate fatigue, while their absence correlated with mild fatigue (p < 0.01). Small positive correlations existed between fatigue and age (Rho = 0.15) and pain (Rho = 0.23) (p < 0.05).
Cancer-related fatigue (CRF) is highly prevalent in individuals with CRC and can be present throughout all phases of the disease. Early screening and management are recommended, prior to surgical treatment.
描述成年结直肠癌（CRC）患者疲劳的患病率。此外，探讨疲劳与社会人口学及临床特征之间的关联和相关性。
在智利一家公立医院，使用简明疲劳量表（BFI）评估处于疾病不同阶段的CRC患者的疲劳情况，使用巴氏指数评估日常生活活动的独立性，使用视觉模拟量表（VAS）评估疼痛感知，使用东部肿瘤协作组标准评估体能状态。采用描述性分析来描述变量。使用卡方检验和斯皮尔曼检验来评估疲劳与其他变量之间的关联。
241名患者参与研究（平均年龄68.9±12.2岁），其中结肠癌最为常见（66.4%）。疲劳在疾病的所有阶段均存在，中度疲劳最为普遍（49.3%），其次是轻度（24.2%）和重度（13.6%）。新诊断患者中重度疲劳的比例更高（p = 0.04）。女性经历中度疲劳的比例高于男性（p < 0.05）。患有三种以上合并症且疼痛严重的患者重度疲劳的比例更高（p < 0.05）。情绪障碍与更严重的疲劳相关，而没有情绪障碍则与较轻的疲劳相关（p = 0.02）。肌肉骨骼疾病与中度疲劳相关，而没有肌肉骨骼疾病则与轻度疲劳相关（p < 0.01）。疲劳与年龄（Rho = 0.15）和疼痛（Rho = 0.23）之间存在小的正相关（p < 0.05）。
癌症相关疲劳（CRF）在CRC患者中高度普遍，且可出现在疾病的所有阶段。建议在手术治疗前进行早期筛查和管理。
