Husebø Anne Marie Lunde, Dalen Ingvild, Søreide Jon Arne, Bru Edvin, Richardson Alison
Research Group of Nursing and Health Sciences, Stavanger University Hospital, Stavanger, Norway.
Department of Public Health, Faculty of Health Sciences, University of Stavanger, Stavanger, Norway.
J Clin Nurs. 2022 Nov;31(21-22):3089-3101. doi: 10.1111/jocn.16135. Epub 2021 Nov 23.
This cross-sectional study aimed to describe cancer-related fatigue (CRF) in colorectal cancer (CRC) patients who were surgically treated with curative intent, identify subgroups at risk of elevated fatigue levels and explore associations between CRF and treatment burden.
CRF is a prominent symptom among cancer patients. In patients treated for CRC, CRF is associated with adjuvant treatments, low quality of life and reduced ability to self-manage.
One hundred thirty-four patients with CRC treated at a Norwegian university hospital between 2016-2018 were included. The Schwartz Cancer Fatigue Scale-6 and the Patient Experience with Treatment and Self-management questionnaires were applied for data collection. Statistical analyses included descriptive statistics and non-parametric approaches to analyse correlations and identify differences between groups. The study adhered to STROBE Statement checklist for reporting of cross-sectional studies.
Median fatigue level was 10.0 (range: 7.0-13.0). Physical fatigue was higher than perceptual fatigue, with medians of 6.0 (interquartile range [IQR]: 3.0-13.0) and 4.0 (IQR: 3.0-12.0), respectively. Higher fatigue levels were associated with age <60 years, advanced cancer and adjuvant treatments. Increased CRF was significantly associated with higher treatment burden on seven of the nine dimensions, adjusted for demographic and clinical variables. The association of fatigue and treatment burden was stronger in survivors <60 years, with advanced cancer, 6-12 months since surgery or who had more comorbid conditions.
This study showed patients at risk of experiencing CRF following CRC treatment. It established proof of associations between CRF and treatment burden and identified subgroups of CRC patients where this association was stronger.
Screening of CRF in CRC patients can help clinicians provide individualized treatment and care to manage CRF. Clinicians should consider the association between CRF and treatment burden, especially in subgroups of CRF patients.
本横断面研究旨在描述接受根治性手术治疗的结直肠癌（CRC）患者的癌症相关疲劳（CRF），识别疲劳水平升高风险的亚组，并探讨CRF与治疗负担之间的关联。
CRF是癌症患者中的一个突出症状。在接受CRC治疗的患者中，CRF与辅助治疗、生活质量低下和自我管理能力下降有关。
纳入2016年至2018年在挪威一家大学医院接受治疗的134例CRC患者。应用施瓦茨癌症疲劳量表-6以及治疗与自我管理患者体验问卷进行数据收集。统计分析包括描述性统计和非参数方法，以分析相关性并识别组间差异。本研究遵循STROBE声明清单报告横断面研究。
疲劳水平中位数为10.0（范围：7.0 - 13.0）。身体疲劳高于感知疲劳，中位数分别为6.0（四分位间距[IQR]：3.0 - 13.0）和4.0（IQR：3.0 - 12.0）。较高的疲劳水平与年龄<60岁、癌症晚期和辅助治疗有关。在调整人口统计学和临床变量后，CRF增加与九个维度中的七个维度上更高的治疗负担显著相关。在年龄<60岁、患有晚期癌症、术后6至12个月或合并症更多的幸存者中，疲劳与治疗负担的关联更强。
本研究显示了CRC治疗后有经历CRF风险的患者。它证实了CRF与治疗负担之间的关联，并识别出CRC患者中这种关联更强的亚组。
对CRC患者进行CRF筛查有助于临床医生提供个体化治疗和护理以管理CRF。临床医生应考虑CRF与治疗负担之间的关联，尤其是在CRF患者亚组中。
