肝细胞中的纤维蛋白原包涵体：一种新型毛玻璃样肝细胞。免疫光镜和电镜特征

Fibrinogen inclusions in liver cells: a new type of ground-glass hepatocyte. Immune light and electron microscopic characterization.

作者信息

Callea F, de Vos R, Togni R, Tardanico R, Vanstapel M J, Desmet V J

出版信息

Histopathology. 1986 Jan;10(1):65-73. doi: 10.1111/j.1365-2559.1986.tb02461.x.

DOI:10.1111/j.1365-2559.1986.tb02461.x

Abstract

A new type of ground-glass hepatocyte is described. The appearance is due to pale, homogeneous, weakly eosinophilic inclusions filling a portion of or the entire hepatocytic cytoplasm. On haematoyxlin and eosin stained sections, these cells closely resemble ground-glass hepatocytes described in other conditions. However, they are negative on special stains for HBsAg and on PAS staining. Immunohistochemically, they reveal a selective and exclusive positivity for fibrinogen. On electron microscopy, the immunoreactive fibrinogen appears as amorphous, fluffy or granular material within dilated cisternae of the rough endoplasmic reticulum. This finding suggests intracellular storage possibly reflecting a defective intracellular transport of fibrinogen.

摘要

描述了一种新型的毛玻璃样肝细胞。其外观是由于苍白、均匀、弱嗜酸性的内含物填充了部分或整个肝细胞细胞质。在苏木精和伊红染色切片上，这些细胞与其他情况下描述的毛玻璃样肝细胞非常相似。然而，它们对HBsAg的特殊染色和PAS染色均为阴性。免疫组织化学显示，它们对纤维蛋白原具有选择性和特异性阳性反应。在电子显微镜下，免疫反应性纤维蛋白原表现为粗面内质网扩张池内的无定形、蓬松或颗粒状物质。这一发现提示细胞内储存，可能反映了纤维蛋白原细胞内运输缺陷。