Bengbu Medical University, Bengbu, Anhui, China.
Sci Rep. 2024 Nov 21;14(1):28869. doi: 10.1038/s41598-024-79072-0.
In China, unhealthy lifestyles, including smoking, alcohol consumption, a lack of exercise, and irrational diets, are relatively common among the elderly population. The objective of this study was to examine the specific associations between poor health-related behaviours and all-cause and cause-specific mortality in older adults. This study involved 5,015 subjects ≥ 60 years of age from the CHARLS database over a 10-year follow-up period. The average age was (67.96 ± 6.39) years. We examined whether lifestyle groups, based on adherence to non-smoking, no-alcohol, moderate exercise, and 18.5 kg/m ≤ BMI< 24 kg/m, were linked with subsequent mortality. Cox proportional hazard models were used to estimate the hazard ratio (HR) and 95% confidence intervals for all-cause and cause-specific mortality of maintaining a healthy lifestyle. In multivariate adjustment model, the risk of all-cause mortality was reduced by 59.2% [HR 0.408 (95% CI 0.333, 0.499)] in the moderate group compared with the unfavorable group. In addition, the risk of all-cause mortality was reduced to 80.5% [HR 0.195 (95% CI 0.150, 0.253)] in the favorable group. The risks of cardiovascular and cerebrovascular diseases, chronic respiratory disease, cancers, and diabetes increased with similar dose-response patterns. The combination of all four healthy lifestyles provided the greatest protection, reducing mortality by 84.5%. In the elderly population, adherence to a healthy lifestyle is associated with a significant reduction in the risk of all-cause and cause-specific mortality.
在中国,包括吸烟、饮酒、缺乏运动和不合理饮食在内的不健康生活方式在老年人群中较为常见。本研究旨在探讨不良健康行为与老年人全因和死因特异性死亡之间的具体关联。本研究纳入了 CHARLS 数据库中 5015 名年龄≥60 岁的受试者,随访 10 年。平均年龄为(67.96±6.39)岁。我们根据是否遵循不吸烟、不饮酒、适度运动和 18.5kg/m²≤BMI<24kg/m²来检查生活方式组与随后的死亡率之间是否存在关联。Cox 比例风险模型用于估计保持健康生活方式与全因和死因特异性死亡率的风险比(HR)和 95%置信区间。在多变量调整模型中,与不良组相比,适度组全因死亡率的风险降低了 59.2%[HR 0.408(95%CI 0.333, 0.499)]。此外,与不良组相比,全因死亡率的风险降低了 80.5%[HR 0.195(95%CI 0.150, 0.253)]。心血管疾病、脑血管疾病、慢性呼吸道疾病、癌症和糖尿病的全因死亡率风险呈相似的剂量-反应模式增加。四项健康生活方式的结合提供了最大的保护,使死亡率降低了 84.5%。在老年人群中,遵循健康的生活方式与全因和死因特异性死亡风险的显著降低相关。