Laboratory of Laser Sports Medicine, School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
Department of rehabilitation, Xiangtan Central Hospital, Xiangtan, China.
J Alzheimers Dis. 2024 Nov;102(2):295-307. doi: 10.1177/13872877241289397. Epub 2024 Oct 29.
The efficacy and safety of 40 Hz gamma transcranial alternating current stimulation (γ-tACS) in Alzheimer's disease (AD) are still uncertain.
This meta-analysis was conducted to investigate the therapeutic potential and safety of 40 Hz γ-tACS for AD.
The meta-analysis was conducted by systematically searching four databases from their start to 28 December 2023. Subgroup analyses were performed to identify the intervention effects of γ-tACS.
Of the 7 included studies, γ-tACS has a notable impact on improving overall cognition [standardized mean difference (SMD): 0.49, 95% CI: 0.09 to 0.89], memory (SMD: 0.79, 95% CI: 0.18 to 1.41), and cholinergic transmission (weighted mean difference: -0.40, 95% CI: -0.43 to -0.37). Furthermore, subgroup analysis revealed that γ-tACS treatment had a substantial impact on enhancing memory targeting the left angular gyrus in both home (SMD: 3.12, 95% CI: 1.54 to 4.70) and non-home settings (SMD: 0.53, 95% CI: 0.24 to 0.82). However, γ-tACS had a positive effect on overall cognition in non-home settings (SMD: 0.55, 95% CI 0.11 to 0.98), but not in home settings (SMD: 0.22, 95% CI -0.76 to 1.20). Additionally, targeting temporo-frontal or bitemporal γ-tACS treatment resulted in improvement in overall cognition (SMD: 0.61, 95% CI: 0.06 to 1.16), but not targeting the left angular gyrus (SMD: 0.22, 95% CI: -0.76 to 1.20).
γ-tACS could be beneficial in enhancing cognition, memory and restoring cholinergic dysfunction in AD. The different selection of stimulation sites plays distinct roles. Meanwhile, AD patients are recommended to receive γ-tACS treatment at home.
40Hz 伽马经颅交流电刺激（γ-tACS）在阿尔茨海默病（AD）中的疗效和安全性仍不确定。
本荟萃分析旨在探讨 40Hzγ-tACS 治疗 AD 的潜在疗效和安全性。
通过系统检索四个数据库，从建库至 2023 年 12 月 28 日，进行荟萃分析。进行亚组分析以确定γ-tACS 的干预效果。
纳入的 7 项研究中，γ-tACS 可显著改善整体认知[标准化均数差（SMD）：0.49，95%置信区间（CI）：0.09 至 0.89]、记忆（SMD：0.79，95%CI：0.18 至 1.41）和胆碱能传递（加权均数差：-0.40，95%CI：-0.43 至-0.37）。此外，亚组分析显示，γ-tACS 治疗对左角回的记忆具有显著影响，无论是在家庭环境[SMD：3.12，95%CI：1.54 至 4.70]还是非家庭环境[SMD：0.53，95%CI：0.24 至 0.82]。然而，γ-tACS 对非家庭环境中的整体认知有积极影响（SMD：0.55，95%CI 0.11 至 0.98），但对家庭环境中无影响（SMD：0.22，95%CI -0.76 至 1.20）。此外，针对颞-额或双颞部的γ-tACS 治疗可改善整体认知（SMD：0.61，95%CI：0.06 至 1.16），但针对左角回的γ-tACS 治疗则无此效果（SMD：0.22，95%CI -0.76 至 1.20）。
γ-tACS 可能有益于增强 AD 患者的认知、记忆和恢复胆碱能功能障碍。不同刺激部位的选择发挥不同的作用。同时，建议 AD 患者在家中接受γ-tACS 治疗。
