成人体外膜肺氧合幸存者的长期健康相关生活质量：一项单中心、横断面研究。

Long-term health related quality of life in adult extracorporeal membrane oxygenation survivors: a single-centre, cross-sectional study.

机构信息

Department of ICU, Sichuan Provincial Peoples Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Department of Respiratory and Critical Care Medicine, Chengdu Wenjiang District People's Hospital, Chengdu, China.

出版信息

BMC Public Health. 2024 Nov 21;24(1):3243. doi: 10.1186/s12889-024-20782-5.

DOI:10.1186/s12889-024-20782-5

PMID:39574051

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11583781/

Abstract

BACKGROUND

This study aimed to evaluate the health-related quality of life of adult survivors of extracorporeal membrane oxygenation and identify the factors influencing their long-term outcomes. The findings are intended to provide a reference for optimizing post-extracorporeal membrane oxygenation care.

METHODS

A cross-sectional survey was conducted with 106 adult extracorporeal membrane oxygenation survivors. Data were collected using the General Information Questionnaire, the 36-item Short Form Health Survey, the Barthel Index, the Post-Traumatic Stress Disorder Rating Scale, and the Nottingham Health Profile Part II. Statistical analyses included the two-sample rank sum test, multi-sample Kruskal-Wallis test, Spearman correlation analysis, and multiple linear regression to assess relationships between health-related quality of life and various factors.

RESULTS

Long-term health-related quality of life scores for extracorporeal membrane oxygenation survivors were 63.72 ± 20.87 for Physical Component Summary(PCS) and 72.69 ± 23.67 for Mental Component Summary (MCS). PCS was positively correlated with the Barthel Index score (r = 0.560, P < 0.01) and negatively correlated with the Post-Traumatic Stress Disorder Rating Scale (r = -0.58, P < 0.01) and Nottingham Health Profile Part II scores (r = -0.757, P < 0.01). MCS showed similar trends, with a positive correlation with the Barthel Index score (r = 0.589, P < 0.01) and negative correlations with the Post-Traumatic Stress Disorder Rating Scale (r = -0.741, P < 0.01) and Nottingham Health Profile Part II (r = -0.647, P < 0.01). Independent factors affecting health-related quality of life included physical health, caregiver type, employment status, Barthel Index score, Post-Traumatic Stress Disorder Rating Scale, and Nottingham Health Profile Part II score, accounting for 82.6% of variability in PCS. MCS was influenced by employment status, place of residence, and the same clinical scales, explaining 73.9% of the variation.

CONCLUSIONS

Adult extracorporeal membrane oxygenation survivors have poor health-related quality of life, particularly in social functioning. Key factors affecting their quality of life include caregiver type, employment status, physical and psychological health scores, and place of residence. Establishing specialized extracorporeal membrane oxygenation clinics is crucial for providing comprehensive care and improving long-term outcomes for survivors.

摘要

背景

本研究旨在评估体外膜氧合成人幸存者的健康相关生活质量，并确定影响其长期预后的因素。研究结果旨在为优化体外膜氧合后护理提供参考。

方法

采用横断面调查方法，对 106 例体外膜氧合成人幸存者进行调查。使用一般信息问卷、36 项简明健康调查问卷、巴氏指数、创伤后应激障碍评定量表和诺丁汉健康调查问卷第二部分收集数据。统计分析包括两样本秩和检验、多组 Kruskal-Wallis 检验、Spearman 相关分析和多元线性回归，以评估健康相关生活质量与各种因素之间的关系。

结果

体外膜氧合幸存者的长期健康相关生活质量评分，生理成分量表（PCS）为 63.72±20.87，心理成分量表（MCS）为 72.69±23.67。PCS 与巴氏指数评分呈正相关（r=0.560，P<0.01），与创伤后应激障碍评定量表（r=-0.58，P<0.01）和诺丁汉健康调查问卷第二部分评分（r=-0.757，P<0.01）呈负相关。MCS 也呈现出相似的趋势，与巴氏指数评分呈正相关（r=0.589，P<0.01），与创伤后应激障碍评定量表（r=-0.741，P<0.01）和诺丁汉健康调查问卷第二部分（r=-0.647，P<0.01）呈负相关。影响健康相关生活质量的独立因素包括身体健康、照顾者类型、就业状况、巴氏指数评分、创伤后应激障碍评定量表和诺丁汉健康调查问卷第二部分评分，占 PCS 变异的 82.6%。MCS 受就业状况、居住地和相同的临床量表影响，解释了 73.9%的变异。