Medical Technology Program, Faculty of Science, Nakhon Phanom University, Nakhon Phanom, 48000, Thailand.
Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Malar J. 2024 Nov 21;23(1):353. doi: 10.1186/s12936-024-05156-x.
The evidences of oxidative stress-related Plasmodium infection may alter the ceruloplasmin levels were inconsistent. This systematic review and meta-analysis aimed to collate and synthesize literatures on malaria and ceruloplasmin concentrations.
The systematic review has been registered with PROSPERO (CRD42023454859). Six electronic databases were systematically searched for investigated ceruloplasmin levels in malaria: ProQuest, EMBASE, MEDLINE, Ovid, PubMed, and Scopus, from their inception to August 2023. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools for cross-sectional, cohort, and case-control studies. Qualitative synthesis was undertaken to summarize findings from the included studies. For quantitative synthesis, a meta-analysis was performed using random-effects models.
A total of 411 articles were retrieved, and nine studies were included in the review. The majority of included studies found significantly increased ceruloplasmin levels in malaria patients compared to uninfected controls. The meta-analysis showed a significant increase of ceruloplasmin in patients with malaria as compared to uninfected controls (P < 0.01, Hedge's g 1.18, 95% CI 0.90-1.47, I 59.19%, eight studies).
The systematic review and meta-analysis consistently revealed a significant rise in ceruloplasmin levels among malaria patients. Further research is essential to understand the variations in ceruloplasmin levels between different Plasmodium species and the severity of malaria in patients.
氧化应激相关的疟原虫感染可能会改变铜蓝蛋白水平，但相关证据并不一致。本系统评价和荟萃分析旨在整理和综合疟疾和铜蓝蛋白浓度相关的文献。
本系统评价已在 PROSPERO（CRD42023454859）上注册。系统地检索了 ProQuest、EMBASE、MEDLINE、Ovid、PubMed 和 Scopus 这六个电子数据库，以获取有关疟疾中铜蓝蛋白水平的研究：从成立到 2023 年 8 月。使用 Joanna Briggs 研究所（JBI）的横断面研究、队列研究和病例对照研究的批判性评估工具评估纳入研究的质量。定性综合用于总结纳入研究的发现。对于定量综合，使用随机效应模型进行荟萃分析。
共检索到 411 篇文章，其中 9 篇研究纳入综述。大多数纳入的研究发现，与未感染对照相比，疟疾病例的铜蓝蛋白水平显著升高。荟萃分析显示，与未感染对照相比，疟疾患者的铜蓝蛋白水平显著升高（P<0.01，Hedge's g 1.18，95%CI 0.90-1.47，I 59.19%，八项研究）。
系统评价和荟萃分析一致表明，疟疾病例的铜蓝蛋白水平显著升高。需要进一步研究以了解不同疟原虫物种之间铜蓝蛋白水平的差异以及患者疟疾的严重程度。
