A Multifunctional Bioadhesive for Bone Augmentation: Tissue Integration Combined with Antioxidant and Antibacterial Effects.

Guided bone regeneration (GBR) is a widely used clinical method for bone augmentation that features a barrier membrane that prevents soft tissue interference with osteogenesis. However, the most used collagen membranes and bone granules often struggle to maintain a stable bone formation space and create a microenvironment conducive to bone regeneration. In this study, a multifunctional bioadhesive (nSF@TA) is obtained from the reaction between nanofiber fibroin (nSF) and tannic acid (TA), which exhibits excellent wet adhesion properties on various substances and maintains a stable osteogenic space through tissue integration. Furthermore, nSF@TA demonstrates remarkable antibacterial and antioxidant capabilities, which effectively mitigate the impact of adverse stimuli, thereby creating a favorable microenvironment for osteogenesis. This approach may pave the way for developing advanced bone graft materials that significantly improve the outcomes of guided bone regeneration.