Guo Zhengnong, Li Miaomiao, Sun Nuo, Song Tingye, Wang Chen
Department of Prosthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, No. 1 Shanghai Road, Nanjing 210029, Jiangsu, P. R. China.
ACS Appl Mater Interfaces. 2024 Dec 4;16(48):65890-65906. doi: 10.1021/acsami.4c14863. Epub 2024 Nov 22.
Guided bone regeneration (GBR) is a widely used clinical method for bone augmentation that features a barrier membrane that prevents soft tissue interference with osteogenesis. However, the most used collagen membranes and bone granules often struggle to maintain a stable bone formation space and create a microenvironment conducive to bone regeneration. In this study, a multifunctional bioadhesive (nSF@TA) is obtained from the reaction between nanofiber fibroin (nSF) and tannic acid (TA), which exhibits excellent wet adhesion properties on various substances and maintains a stable osteogenic space through tissue integration. Furthermore, nSF@TA demonstrates remarkable antibacterial and antioxidant capabilities, which effectively mitigate the impact of adverse stimuli, thereby creating a favorable microenvironment for osteogenesis. This approach may pave the way for developing advanced bone graft materials that significantly improve the outcomes of guided bone regeneration.
引导性骨再生（GBR）是一种广泛应用于骨增量的临床方法，其特点是使用屏障膜来防止软组织干扰骨生成。然而，最常用的胶原膜和骨颗粒往往难以维持稳定的骨形成空间并创造有利于骨再生的微环境。在本研究中，通过纳米纤维丝素蛋白（nSF）与单宁酸（TA）反应获得了一种多功能生物粘合剂（nSF@TA），它在各种物质上表现出优异的湿粘附性能，并通过组织整合维持稳定的成骨空间。此外，nSF@TA具有显著的抗菌和抗氧化能力，可有效减轻不良刺激的影响，从而为骨生成创造有利的微环境。这种方法可能为开发先进的骨移植材料铺平道路，显著改善引导性骨再生的效果。
