Ferenczi E A, Wang W, Biswas A, Pottala T, Dong Y, Chan A K, Albanese M A, Sohur R S, Jia T, Mastro K J, Sabatini B L
bioRxiv. 2024 Nov 9:2024.11.08.622712. doi: 10.1101/2024.11.08.622712.
The globus pallidus externa (GPe) is a heterogenous nucleus of the basal ganglia, with intricate connections to other basal ganglia nuclei, as well as direct connections to the cortex. The anatomic, molecular and electrophysiologic properties of cortex-projecting pallidocortical neurons are not well characterized. Here we show that pallidocortical neurons project to diverse motor and non-motor cortical regions, are organized topographically in the GPe, and segregate into two distinct electrophysiological and molecular phenotypes. In addition, we find that the GPe receives direct synaptic input back from deep layers of diverse motor and non-motor cortical regions, some of which form reciprocal connections onto pallidocortical neurons. These results demonstrate the existence of a fast, closed-loop circuit between the GPe and the cortex which is ideally positioned to integrate information about behavioral goals, internal states, and environmental cues to rapidly modulate behavior.
苍白球外侧部（GPe）是基底神经节的一个异质性核团，与其他基底神经节核团有着复杂的联系，并且与皮质有直接连接。投射到皮质的苍白球皮质神经元的解剖学、分子学和电生理学特性尚未得到充分表征。在这里，我们表明苍白球皮质神经元投射到不同的运动和非运动皮质区域，在GPe中按拓扑结构组织，并分为两种不同的电生理和分子表型。此外，我们发现GPe从不同运动和非运动皮质区域的深层接受直接的突触输入，其中一些在苍白球皮质神经元上形成相互连接。这些结果证明了GPe和皮质之间存在一个快速的闭环回路，该回路处于理想位置，能够整合有关行为目标、内部状态和环境线索的信息，以快速调节行为。
