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血清基质金属蛋白酶9和/或D - 二聚体水平是否为识别严重冠状动脉粥样硬化患者腹主动脉瘤的标志物？

Is Serum Matrix Metalloproteinase 9 and/or D-Dimer Levels a Marker for Identifying Abdominal Aortic Aneurysms in Patients with Significant Coronary Atherosclerosis?

作者信息

Brie Diduta Alina, Jianu Adelina Maria, Popescu Roxana, Brie Daniel Miron, Boruga Madalina

机构信息

Department of Cellular and Molecular Biology, "Victor Babeș" University of Medicine and Pharmacy, Timișoara, Romania.

ANAPATMOL Research Center, "Victor Babeș" University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.

出版信息

Curr Health Sci J. 2024 Jul-Sep;50(3):405-410. doi: 10.12865/CHSJ.50.03.07. Epub 2024 Sep 30.

DOI:10.12865/CHSJ.50.03.07
PMID:39574820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11578357/
Abstract

Our research aims to find a connection between the levels of MMP-9 and D-dimers in the blood and the prevalence of AAAs in subjects with atherosclerotic coronary disease. We selected fifty patients from each group and measured their MMP-9 and D-dimer levels in the blood. We discovered that in subjects with significant coronary disease and angina pectoris, the level of MMP-9 is higher compared to the subjects with angina pectoris but without significant coronary disease. When comparing this group with those with significant coronary disease and AAA, the level of MMP-9 is lower. Additionally, the D-dimer level was significantly higher in subjects with both AAA and significant coronary atherosclerosis compared to patients with significant coronary disease alone or those without significant coronary disease or AAAs. Subjects with significant coronary disease and AAA have elevated levels of MMP-9 and D-dimer compared to patients with significant coronary disease alone or without coronary artery disease or AAAs. These two factors could be used as indicators for diagnosing AAA in patients with angina pectoris.

摘要

我们的研究旨在探寻血液中基质金属蛋白酶-9（MMP-9）和D-二聚体水平与动脉粥样硬化性冠状动脉疾病患者腹主动脉瘤（AAA）患病率之间的联系。我们从每组中选取了50名患者，并测量了他们血液中的MMP-9和D-二聚体水平。我们发现，在患有严重冠状动脉疾病和心绞痛的患者中，MMP-9水平高于患有心绞痛但无严重冠状动脉疾病的患者。将该组与患有严重冠状动脉疾病和AAA的患者进行比较时，MMP-9水平较低。此外，与仅患有严重冠状动脉疾病的患者或无严重冠状动脉疾病或AAA的患者相比，同时患有AAA和严重冠状动脉粥样硬化的患者D-二聚体水平显著更高。与仅患有严重冠状动脉疾病的患者或无冠状动脉疾病或AAA的患者相比，患有严重冠状动脉疾病和AAA的患者MMP-9和D-二聚体水平升高。这两个因素可作为诊断心绞痛患者是否患有AAA的指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa4/11578357/7418f464c718/CHSJ-50-03-405-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa4/11578357/fcd7f1cbe2b6/CHSJ-50-03-405-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa4/11578357/b61600957705/CHSJ-50-03-405-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa4/11578357/fa0f8934f28b/CHSJ-50-03-405-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa4/11578357/7418f464c718/CHSJ-50-03-405-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa4/11578357/fcd7f1cbe2b6/CHSJ-50-03-405-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa4/11578357/b61600957705/CHSJ-50-03-405-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa4/11578357/fa0f8934f28b/CHSJ-50-03-405-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa4/11578357/7418f464c718/CHSJ-50-03-405-fig4.jpg

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本文引用的文献

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Aortic aneurysms in patients with atherosclerotic coronary artery disease in the southwestern region of Romania - clinical and histopathological study.罗马尼亚西南部粥样硬化性冠状动脉疾病患者的主动脉瘤——临床和组织病理学研究。
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D-Dimer Is a Diagnostic Biomarker of Abdominal Aortic Aneurysm in Patients With Peripheral Artery Disease.D-二聚体是外周动脉疾病患者腹主动脉瘤的诊断生物标志物。
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