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多西环素诱导的中毒性表皮坏死松解症：一例报告及文献综述

Toxic Epidermal Necrolysis Induced by Doxycycline: A Case Report and Literature Review.

作者信息

Sandakly Nicolas, El Koubayati Georgio, Issa Lea, Abdallah Rim M, Nasser Selim, Haddad Fady

机构信息

Department of Internal Medicine, Lebanese University Faculty of Medicine, Beirut, LBN.

Department of Internal Medicine and Clinical Immunology, Lebanese University Faculty of Medicine, Beirut, LBN.

出版信息

Cureus. 2024 Oct 22;16(10):e72098. doi: 10.7759/cureus.72098. eCollection 2024 Oct.

DOI:10.7759/cureus.72098
PMID:39574993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11581461/
Abstract

Lyell syndrome, also known as toxic epidermal necrolysis (TEN), is a rare but life-threatening skin condition, often triggered by certain medications. Antiepileptics, allopurinol, and some nonsteroidal anti-inflammatory drugs are the most common causes. Some antibiotics are also common culprits, although tetracyclines are rarely linked to this condition. We hereby report a case of TEN induced by doxycycline in an 18-year-old girl who was taking the drug for the treatment of acne.

摘要

莱尔综合征，又称中毒性表皮坏死松解症（TEN），是一种罕见但危及生命的皮肤病，通常由某些药物引发。抗癫痫药、别嘌醇和一些非甾体抗炎药是最常见的病因。一些抗生素也是常见的罪魁祸首，尽管四环素很少与这种疾病相关。我们在此报告一例18岁女孩因服用强力霉素治疗痤疮而诱发中毒性表皮坏死松解症的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/a9e444381bc7/cureus-0016-00000072098-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/3007f004d6df/cureus-0016-00000072098-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/b1fa4d144996/cureus-0016-00000072098-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/0bd4c8c0d30d/cureus-0016-00000072098-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/ab6b9ef44270/cureus-0016-00000072098-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/427709beba50/cureus-0016-00000072098-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/a9e444381bc7/cureus-0016-00000072098-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/3007f004d6df/cureus-0016-00000072098-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/b1fa4d144996/cureus-0016-00000072098-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/0bd4c8c0d30d/cureus-0016-00000072098-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/ab6b9ef44270/cureus-0016-00000072098-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/427709beba50/cureus-0016-00000072098-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70bd/11581461/a9e444381bc7/cureus-0016-00000072098-i06.jpg

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本文引用的文献

1
Accuracy of SCORTEN in predicting mortality in toxic epidermal necrolysis.SCORTEN 在预测中毒性表皮坏死松解症死亡率中的准确性。
BMC Med Inform Decis Mak. 2022 Oct 19;22(1):273. doi: 10.1186/s12911-022-02013-2.
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Toxic epidermal necrolysis induced by doxycycline.多西环素诱导的中毒性表皮坏死松解症。
Int J Dermatol. 2021 Oct;60(10):e398-e400. doi: 10.1111/ijd.15470. Epub 2021 Mar 1.
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Systemic therapies for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: a SCORTEN-based systematic review and meta-analysis.史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的全身治疗：基于SCORTEN的系统评价和荟萃分析。
J Eur Acad Dermatol Venereol. 2021 Jan;35(1):159-171. doi: 10.1111/jdv.16685. Epub 2020 Jul 23.
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Toxic epidermal necrolysis syndrome induced by tigecycline: a case report.替加环素引起的中毒性表皮坏死松解症：一例报告。
J Int Med Res. 2020 May;48(5):300060520922416. doi: 10.1177/0300060520922416.
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Tetracycline Re-exposure-Induced Toxic Epidermal Necrolysis.四环素再次暴露诱发中毒性表皮坏死松解症。
Am J Ther. 2019 Nov/Dec;26(6):e745-e747. doi: 10.1097/MJT.0000000000000904.
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How Does SCORTEN Score?SCORTEN评分是如何计算的？
J Burn Care Res. 2018 Jun 13;39(4):555-561. doi: 10.1093/jbcr/irx016.
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Hereditary angioedema caused by the p.Thr309Lys mutation in the F12 gene: a multifactorial disease.由F12基因中p.Thr309Lys突变引起的遗传性血管性水肿：一种多因素疾病。
J Allergy Clin Immunol. 2013 Oct;132(4):986-9.e1-5. doi: 10.1016/j.jaci.2013.04.032. Epub 2013 Jul 10.
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The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis.史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的现有认识。
Expert Rev Clin Immunol. 2011 Nov;7(6):803-13; quiz 814-5. doi: 10.1586/eci.11.66.
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A case report of doxycycline-induced Stevens-Johnson syndrome.多西环素诱导的 Stevens-Johnson 综合征病例报告。
Cornea. 2011 May;30(5):595-7. doi: 10.1097/ICO.0b013e3181f05773.
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Disseminated Strongyloides stercoralis infection with a cutaneous presentation in an immunosuppressed patient.一名免疫抑制患者出现皮肤表现的播散性粪类圆线虫感染。
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