University of Pittsburgh Medical School, Pittsburgh, PA, USA.
Cornea. 2011 May;30(5):595-7. doi: 10.1097/ICO.0b013e3181f05773.
To report the clinical findings of a case of Stevens-Johnson syndrome (SJS) precipitated by the use of systemic doxycycline.
Case report.
A 49-year-old man developed SJS with ocular involvement after doxycycline use for respiratory symptoms. The patient developed persistent 2+ conjunctival injection and foreshortening of the conjunctival fornices in both eyes. The right eye had a 3 × 3.4 mm corneal epithelial defect with 50% thinning. The left eye had a 2.6 × 3 mm corneal ulcer with a central perforation and a flat anterior chamber with 360 degrees of iridocorneal touch.
This case illustrates the unusual presentation of SJS induced by doxycycline. The prevalent use of systemic doxycycline in the practice of ophthalmology for eyelid-related and ocular surface disorders coupled with the detrimental long-term sequelae of SJS renders a careful reevaluation for alternatives.
报告一例由全身性多西环素引起的史蒂文斯-约翰逊综合征（SJS）的临床发现。
病例报告。
一名 49 岁男性因呼吸道症状使用多西环素后出现 SJS，伴有眼部受累。患者双眼持续性 2+结膜充血和结膜穹窿缩短。右眼角膜上皮缺损 3×3.4mm，厚度减少 50%。左眼有 2.6×3mm 的角膜溃疡，中央穿孔，前房平坦，虹膜角膜接触 360 度。
本例说明了多西环素引起的 SJS 不常见的表现。眼科实践中广泛使用全身性多西环素治疗眼睑相关和眼表面疾病，再加上 SJS 的长期不良后果，需要仔细重新评估替代药物。
