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Does early discontinuation of topical 4% 5-fluorouracil affect lesion clearance for actinic keratosis? Results from a dose-ranging study.早期停用局部4% 5-氟尿嘧啶是否会影响光化性角化病的皮损清除？一项剂量范围研究的结果。
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The State of the Art in the Treatment of Actinic Keratosis and Field Cancerization: A Narrative Review.光化性角化病与场癌化的治疗现状：一项叙述性综述
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Management of Local Skin Reactions Caused by 5-FU 4% Cream for the Treatment of Actinic Keratosis: A Delphi Consensus.4% 5-氟尿嘧啶乳膏治疗光化性角化病引起的局部皮肤反应的管理：德尔菲共识
Dermatol Pract Concept. 2025 Apr 1;15(2):5787. doi: 10.5826/dpc.1502a5787.

本文引用的文献

1
European consensus-based interdisciplinary guideline for diagnosis, treatment and prevention of actinic keratoses, epithelial UV-induced dysplasia and field cancerization on behalf of European Association of Dermato-Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes).欧洲基于共识的跨学科指南：光化性角化病、上皮紫外线诱导发育不良和皮肤癌前病变的诊断、治疗和预防，代表了欧洲皮肤病肿瘤学会、欧洲皮肤病学会、欧洲皮肤性病学会和医学专家联盟（Union Européenne des Médecins Spécialistes）。
J Eur Acad Dermatol Venereol. 2024 Jun;38(6):1024-1047. doi: 10.1111/jdv.19897. Epub 2024 Mar 7.
2
Intensity of Local Skin Reactions During 5-Fluorouracil Treatment Related to the Number of Actinic Keratosis Lesions: A Post Hoc, Exploratory Analysis.5-氟尿嘧啶治疗期间局部皮肤反应强度与光化性角化病皮损数量的关系：一项事后探索性分析。
Dermatol Ther (Heidelb). 2022 Feb;12(2):467-479. doi: 10.1007/s13555-021-00668-9. Epub 2021 Dec 26.
3
Efficacy, Safety, and Tolerability of 4% 5-Fluorouracil Cream in a Novel Patented Aqueous Cream Containing Peanut Oil Once Daily Compared With 5% 5-Fluorouracil Cream Twice Daily: Meeting the Challenge in the Treatment of Actinic Keratosis.与每日两次使用5% 5-氟尿嘧啶乳膏相比，每日一次使用含花生油的新型专利水性乳膏中4% 5-氟尿嘧啶乳膏治疗光化性角化病的疗效、安全性和耐受性：应对治疗挑战
J Drugs Dermatol. 2016 Oct 1;15(10):1218-1224.

Does early discontinuation of topical 4% 5-fluorouracil affect lesion clearance for actinic keratosis? Results from a dose-ranging study.

作者信息

Heppt Markus V, Ulrich Claas

机构信息

Department of Dermatology, Uniklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CC ER-EMN), Erlangen, Germany.

出版信息

J Eur Acad Dermatol Venereol. 2025 Aug;39(8):e675-e677. doi: 10.1111/jdv.20441. Epub 2024 Nov 22.

DOI:10.1111/jdv.20441
PMID:39575853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12291012/
Abstract
摘要