Pandhare Amol B, Mulik Swapnajit V, Malavekar Dhanaji B, Kim Jin H, Khot Vishwajeet M, Kumar Pawan, Sutar Santosh S, Dongale Tukaram D, Patil Rajendra P, Delekar Sagar D
Department of Chemistry, Shivaji University, Kolhapur 416 004, MS, India.
Department of Chemistry, M.H. Shinde Mahavidyalaya, Tisangi, Gaganbavda, Kolhapur 416 206, MS, India.
Langmuir. 2024 Dec 10;40(49):25902-25918. doi: 10.1021/acs.langmuir.4c03228. Epub 2024 Nov 22.
In this study, various compositions of α-FeO, LiFeO, where = 0.1, 0.3, and 0.5, along with chitosan (CTS)-coated LiFeO nanomaterials (NMs), were synthesized using a sol-gel method. Rietveld refinement analysis indicated a predominance of the rhombohedral phase for lower Li-doped content ( = 0.1) and a transition to cubic crystal structures at higher Li-doped content ( = 0.3 and 0.5) within the host lattice. Field emission scanning electron microscopy (FE-SEM) images revealed irregular spherical morphologies, while transmission electron microscopy (TEM) images showed average particle sizes ranging from 19 to 40 nm across the various NMs. Superconducting quantum interference device (SQUID) analysis demonstrated a ferromagnetic nature with the highest saturation magnetization measured at 49.84 emu/g for LiFeO NMs. X-ray photoelectron spectra (XPS) exhibited Fe 2p and Fe 2p peaks at 712.60 and 726.13 eV, respectively, Li 1s at 57.58 eV, and O 1s at 533.44 eV for the representative samples; these characteristic XPS peaks shifted to a lower binding energy for CTS-coated LiFeO NMs. Hyperthermia studies demonstrated that the Li-doped samples reached a temperature range between 42 and 44 °C under an alternating current (AC) magnetic field applied at 167.6 to 335.2 Oe, with a constant frequency of 278 kHz. The specific absorption rate (SAR) was recorded as 265.11 W/g for LiFeO and 153.48 W/g for CTS-coated LiFeO NMs, both surpassing the SAR values of the other samples. Furthermore, various machine learning techniques were utilized to analyze how different synthesis conditions and material properties affected the heating efficiency and SAR values of the synthesized materials. The study also suggests an optimized set of guidelines and heuristics to enhance the heating performance and SAR values of these materials. Finally, magnetic CTS-coated LiFeO NMs exhibited a higher cell viability, as confirmed by MTT assays conducted on the NRK 52 E normal cell line.
在本研究中，采用溶胶-凝胶法合成了α-FeO、LiFeO（其中=0.1、0.3和0.5）的各种组合物，以及壳聚糖（CTS）包覆的LiFeO纳米材料（NMs）。Rietveld精修分析表明，在主体晶格中，低锂掺杂含量（=0.1）时菱面体相占主导，而高锂掺杂含量（=0.3和0.5）时转变为立方晶体结构。场发射扫描电子显微镜（FE-SEM）图像显示出不规则的球形形态，而透射电子显微镜（TEM）图像显示各种纳米材料的平均粒径在19至40nm之间。超导量子干涉装置（SQUID）分析表明具有铁磁性质，LiFeO纳米材料的饱和磁化强度最高，为49.84emu/g。X射线光电子能谱（XPS）显示代表性样品的Fe 2p和Fe 2p峰分别位于712.60和726.13eV，Li 1s位于57.58eV，O 1s位于533.44eV；对于CTS包覆的LiFeO纳米材料，这些特征性XPS峰向较低结合能移动。热疗研究表明，在167.6至335.2Oe的交变电流（AC）磁场、278kHz的恒定频率下，锂掺杂样品的温度范围达到42至44°C。LiFeO的比吸收率（SAR）记录为265.11W/g，CTS包覆的LiFeO纳米材料的SAR为153.48W/g，两者均超过其他样品的SAR值。此外，利用各种机器学习技术分析了不同的合成条件和材料性能如何影响合成材料的加热效率和SAR值。该研究还提出了一套优化的指导方针和启发式方法，以提高这些材料的加热性能和SAR值。最后，如对NRK 52 E正常细胞系进行的MTT试验所证实，磁性CTS包覆的LiFeO纳米材料表现出更高的细胞活力。
