喉鳞状细胞癌患者的衰弱状况与生存结局
Frailty and the Survival Outcomes of Patients With Laryngeal Squamous Cell Cancer.
作者信息
McCann Cameron, Hurley Rhona, McGovern Josh, Knight Katrina, Rattray Nicholas J W, Douglas Catriona M
机构信息
Department of Otolaryngology/Head and Neck Surgery, Glasgow Royal Infirmary, Glasgow, UK.
Department of Otolaryngology/Head and Neck Surgery, Queen Elizabeth University Hospital, Glasgow, UK.
出版信息
Head Neck. 2025 Apr;47(4):1079-1092. doi: 10.1002/hed.27951. Epub 2024 Nov 22.
BACKGROUND
Frailty increases the risk of mortality in the head and neck cancer population. This study examines the association between frailty and survival outcomes in patients with laryngeal squamous cell cancer (LSCC).
METHOD
Retrospective data collection from patients in the West of Scotland diagnosed with LSCC between 2014 and 2020. The Modified Five Item Frailty Index (mFI-5) measures frailty and categorizes patients according to their level of frailty. Statistical tests used were the Mann-Whitney U-test or ANOVA for differences in means and survival analyses for overall survival time.
RESULTS
There were 867 patients included. Seventy-eight percent (n = 676) of patients were deemed frail. Median survival for "not frail" patients was 78 months and "severely frail" was 23 months. The palliative treatment group had worse overall survival outcomes compared to curative (hazard ratio (HR) of 7.96, p < 0.001).
CONCLUSION
This study demonstrates frailty is common in patients with LSCC and leads to worse mortality and survival outcomes.
背景
衰弱会增加头颈癌患者的死亡风险。本研究探讨了喉鳞状细胞癌（LSCC）患者衰弱与生存结局之间的关联。
方法
回顾性收集2014年至2020年间在苏格兰西部被诊断为LSCC的患者的数据。改良五项衰弱指数（mFI-5）用于衡量衰弱程度，并根据患者的衰弱水平进行分类。所使用的统计检验方法为曼-惠特尼U检验或方差分析以比较均值差异，并进行总生存时间的生存分析。
结果
共纳入867例患者。78%（n = 676）的患者被认为衰弱。“非衰弱”患者的中位生存期为78个月，“严重衰弱”患者为23个月。与根治性治疗组相比，姑息治疗组的总生存结局更差（风险比（HR）为7.96，p < 0.001）。
结论
本研究表明，衰弱在LSCC患者中很常见，并导致更差的死亡率和生存结局。
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