肿瘤免疫逃逸中的补体调节
Complement regulation in tumor immune evasion.
作者信息
Liu Guijun, He Xuxiao, Zhao Gaoxiang, Lu Zhimin
机构信息
Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou, Zhejiang 310029, China; Zhejiang University Cancer Center, Hangzhou, Zhejiang 310029, China.
Department of Oncology, Cancer Institute of The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, Shandong 266061, China.
出版信息
Semin Immunol. 2024 Nov;76:101912. doi: 10.1016/j.smim.2024.101912. Epub 2024 Nov 22.
The complement system plays crucial roles in both innate and adaptive immune responses, facilitating the elimination of pathogens such as microorganisms and damaged cells, including cancer cells. It is tightly regulated and integrated with cell-mediated immunity. In the tumor microenvironment, the complement system performs both immune and nonimmune functions in tumor and immune cells through pathways that depend on or are independent of complement activation, thereby promoting immune evasion and tumor progression.
补体系统在固有免疫和适应性免疫反应中均发挥着关键作用，有助于清除病原体，如微生物以及受损细胞，包括癌细胞。它受到严格调控，并与细胞介导的免疫相互整合。在肿瘤微环境中，补体系统通过依赖或不依赖补体激活的途径，在肿瘤细胞和免疫细胞中发挥免疫和非免疫功能，从而促进免疫逃逸和肿瘤进展。
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