Marchant R E, Anderson J M, Castillo E, Hiltner A
J Biomed Mater Res. 1986 Feb;20(2):153-68. doi: 10.1002/jbm.820200205.
The ability of a biomaterial to withstand the rigors of the harsh biologic environment is an important consideration when considering a material for long-term biomedical applications. Using a cage implant system, the effects of an intense inflammatory reaction on cast Biomer have been investigated. The inflammatory response to cast Biomer was greatly increased by coimplanting Biomer films with a cytotoxic poly(vinyl chloride) (PVC) in rats for a period of 21 days. Cast Biomer films were characterized by weight, advancing contact angle with water in air, attenuated total reflectance infrared spectroscopy and scanning electron microscopy (SEM). The analyses were performed before any treatment, after autoclaving and sonication, and after 21 days implantation with the cytotoxic (PVC) in rats. The results of the study indicated that cast Biomer does not undergo significant chemical degradation when subjected to the effects of an intense inflammatory reaction for 21 days. Implantation does, however, lead to rearrangement that results in a more polar and hydrophilic surface, suggesting that the polymer adapts to the hydrophilic environment of the inflammatory exudate.
在考虑将一种材料用于长期生物医学应用时，生物材料耐受恶劣生物环境考验的能力是一个重要的考量因素。利用笼式植入系统，研究了强烈炎症反应对铸型Biomer的影响。在大鼠体内将Biomer薄膜与细胞毒性聚氯乙烯（PVC）共同植入21天，铸型Biomer的炎症反应大大增强。铸型Biomer薄膜通过重量、在空气中与水的前进接触角、衰减全反射红外光谱和扫描电子显微镜（SEM）进行表征。分析在任何处理之前、高压灭菌和超声处理之后以及在大鼠体内与细胞毒性（PVC）共同植入21天之后进行。研究结果表明，铸型Biomer在受到强烈炎症反应影响21天时不会发生显著的化学降解。然而，植入确实会导致重排，从而产生一个更具极性和亲水性的表面，这表明聚合物适应了炎性渗出物的亲水环境。
