Wang Huihang, Zhong Huifen, Zhang Jingjin, Wei Wei, Cui Xiaoyuan, Zheng Weidong
Department of Ophthalmology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China; Department of Ophthalmology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China; Fujian Institute of Ophthalmology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China; Fujian Provincial Clinical Medical Research Center of Eye Diseases and Optometry, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Department of Ophthalmology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China; Department of Ophthalmology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China; Fujian Institute of Ophthalmology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China; Fujian Provincial Clinical Medical Research Center of Eye Diseases and Optometry, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Photodiagnosis Photodyn Ther. 2024 Dec;50:104412. doi: 10.1016/j.pdpdt.2024.104412. Epub 2024 Nov 21.
To evaluate the impact of repeated low-level red-light (RLRL) therapy on choroidal thickness and blood flow in pediatric myopia.
A three-month trial (April 1, 2023 - September 30, 2023) was conducted involving 44 children (ages 6-16) with myopia. Participants underwent RLRL therapy at home twice daily for five days per week, with each session lasting three minutes. Assessments at baseline, one month, and three months included cycloplegic refraction, best-corrected visual acuity (BCVA), intraocular pressure (IOP), ocular biometrics, swept-source optical coherence tomography angiography (SS-OCTA), slit-lamp, and fundus examinations.
The study included 44 children (average age: 9.79 years; 56.82 % male). RLRL therapy significantly increased subfoveal choroidal thickness (Baseline: 272.82 ± 64.01 μm; 1-month: 297.77 ± 72.94 μm; 3-month: 298.77 ± 77.17 μm, p = 0.001), reduced axial length (Baseline: 24.97 ± 1.47 mm; 3-month: 24.88 ± 1.38 mm, p = 0.002), and showed a marginal regression in spherical equivalent (p = 0.055). Significant elevations in choroidal vessel volume and thickness were noted, with positive correlations intensifying with distance from the fovea.
RLRL therapy shows promise in managing pediatric myopia by increasing choroidal vessel volume and thickness, potentially mitigating myopia progression.
评估重复低强度红光（RLRL）疗法对儿童近视脉络膜厚度和血流的影响。
进行了为期三个月的试验（2023年4月1日至2023年9月30日），纳入44名6至16岁的近视儿童。参与者在家中每天接受两次RLRL治疗，每周五天，每次治疗持续三分钟。在基线、一个月和三个月时的评估包括散瞳验光、最佳矫正视力（BCVA）、眼压（IOP）、眼部生物测量、扫频光学相干断层扫描血管造影（SS-OCTA）、裂隙灯和眼底检查。
该研究包括44名儿童（平均年龄：9.79岁；男性占56.82%）。RLRL疗法显著增加了黄斑中心凹下脉络膜厚度（基线：272.82±64.01μm；1个月：297.77±72.94μm；3个月：298.77±77.17μm，p = 0.001），减少了眼轴长度（基线：24.97±1.47mm；3个月：24.88±1.38mm，p = 0.002），并且等效球镜度有轻微下降（p = 0.055）。脉络膜血管体积和厚度显著增加，且随着与黄斑中心凹距离的增加，正相关性增强。
RLRL疗法通过增加脉络膜血管体积和厚度，在控制儿童近视方面显示出前景，可能减缓近视进展。
