Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Ophthalmology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Transl Vis Sci Technol. 2024 Oct 1;13(10):29. doi: 10.1167/tvst.13.10.29.
To investigate the long-term effects of repeated low-level red light (RLRL) therapy on the axial length (AL), spherical equivalent (SE), and choroidal parameters.
Two hundred eight myopic eyes were recruited. The RLRL group included 100 eyes, whereas the control group included 108 eyes. Throughout the one-year follow-up period, changes in AL and SE were recorded for both groups. The RLRL group underwent additional choroidal imaging, and changes in choroidal thickness (CT), choroidal vascularity (CV), and choriocapillaris luminal area (CLA) were assessed before and after RLRL therapy.
During the follow-up period, the changing trends in AL and SE differed significantly between the RLRL and control groups. In the RLRL group, AL decreased at three and six months (both P < 0.05) and returned to pretreatment values at 12 months (P = 0.453). In contrast, AL increased significantly throughout the follow-up period (three, six, and 12 months) in the control group (all P < 0.001). The SE increased significantly during the entire follow-up period in the RLRL group (all P < 0.001), whereas it decreased significantly in the control group (all P < 0.05). Regarding choroidal parameters, significant improvements were observed in CT, CV and CLA throughout the follow-up period (all P < 0.05), and changes in most choroidal parameters were significantly correlated with changes in AL and SE during the follow-up period (all P < 0.05). Furthermore, AL, SE, and most choroidal parameters showed significant correlations between changes at three and 12 months (all P < 0.05).
RLRL therapy significantly improved choroidal blood perfusion and circulation, which may explain the observed slowing or reversal of myopia progression in the RLRL group. Thus RLRL therapy may be a novel and effective method for controlling myopia. Furthermore, the short-term effect of photobiomodulation therapy (i.e., changes at three months) can be used to predict the long-term effects (i.e., changes at 12 months).
In this study, RLRL therapy showed a significant control effect on the development of axial length and spherical equivalent. RLRL therapy also promoted the choroidal blood perfusion and circulation. RLRL therapy could be a novel and effective method for myopia control.
研究重复低水平红光（RLRL）治疗对眼轴（AL）、等效球镜（SE）和脉络膜参数的长期影响。
招募了 208 只近视眼。RLRL 组包括 100 只眼，对照组包括 108 只眼。在整个 1 年的随访期间，记录两组 AL 和 SE 的变化。RLRL 组还进行了额外的脉络膜成像，并评估 RLRL 治疗前后脉络膜厚度（CT）、脉络膜血管密度（CV）和脉络膜毛细血管腔面积（CLA）的变化。
在随访期间，RLRL 组和对照组的 AL 和 SE 变化趋势明显不同。RLRL 组中，AL 在 3 个月和 6 个月时（均 P < 0.05）下降，12 个月时恢复到治疗前水平（P = 0.453）。相反，对照组的 AL 在整个随访期间均显著增加（均 P < 0.001）。RLRL 组的 SE 在整个随访期间均显著增加（均 P < 0.001），而对照组的 SE 则显著降低（均 P < 0.05）。关于脉络膜参数，在整个随访期间，CT、CV 和 CLA 均显著改善（均 P < 0.05），并且在随访期间，AL 和 SE 的大部分变化与脉络膜参数的变化显著相关（均 P < 0.05）。此外，AL、SE 和大多数脉络膜参数在 3 个月和 12 个月时的变化之间存在显著相关性（均 P < 0.05）。
RLRL 治疗显著改善了脉络膜的血液灌注和循环，这可能解释了 RLRL 组近视进展的减缓或逆转。因此，RLRL 治疗可能是一种控制近视的新方法。此外，光生物调节治疗的短期效果（即 3 个月时的变化）可用于预测长期效果（即 12 个月时的变化）。
