急性失代偿性心力衰竭中的高渗盐水（HSHF）
Hypertonic saline in acute decompensated heart failure (HSHF).
作者信息
Agrawal Shweta, Abhishek Batta Sunil, Rao Tarun, Selvam Sumithra
机构信息
Department of Cardiology, St. John's medical college and hospital, Bangalore, India.
William Harvey Hospital, Ashford, Kent, England, UK.
出版信息
Indian Heart J. 2024 Nov-Dec;76(6):418-420. doi: 10.1016/j.ihj.2024.11.246. Epub 2024 Nov 22.
Abstract
Hypertonic saline with high dose furosemide improves refractory heart failure. In this case series of 10 patients of refractory acute decompensated heart failure, effect of HSS with furosemide was compared with furosemide alone. Patients responded to the therapy better, with faster decongestion, without significant adverse effects or worsening renal function. Hence an adequately powered, randomized study is required to assess the veracity of findings in this case series of hypertonic saline in diuretic resistant acute decompensated heart failure on optimal therapy. Based on present study, hypertonic saline looks like a promising option in the management of refractory heart failure.
摘要
高渗盐水联合大剂量呋塞米可改善难治性心力衰竭。在这个包含10例难治性急性失代偿性心力衰竭患者的病例系列中，将高渗盐水联合呋塞米的效果与单用呋塞米进行了比较。患者对该治疗反应更好，消肿更快，且无明显不良反应或肾功能恶化。因此，需要进行一项样本量充足的随机研究，以评估该病例系列中关于高渗盐水治疗利尿剂抵抗性急性失代偿性心力衰竭的最佳疗法的研究结果的准确性。基于目前的研究，高渗盐水在难治性心力衰竭的治疗中似乎是一个有前景的选择。
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本文引用的文献
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Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure: A U.S. Center's Experience.高渗盐水在难治性急性失代偿性心力衰竭中的实际应用：美国中心的经验。
JACC Heart Fail. 2020 Mar;8(3):199-208. doi: 10.1016/j.jchf.2019.10.012. Epub 2020 Feb 5.
2
Effects of hypertonic saline solution on body weight and serum creatinine in patients with acute decompensated heart failure.高渗盐溶液对急性失代偿性心力衰竭患者体重和血清肌酐的影响。
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Hypertonic saline with furosemide for the treatment of acute congestive heart failure: a systematic review and meta-analysis.高渗盐水联合呋塞米治疗急性充血性心力衰竭：一项系统评价和荟萃分析。
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