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Hypertonic saline in acute decompensated heart failure (HSHF).急性失代偿性心力衰竭中的高渗盐水（HSHF）
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2
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3
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4
What are the effects of hypertonic saline plus furosemide in acute heart failure?高渗盐水加呋塞米治疗急性心力衰竭有哪些效果？
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Comparison of salt with low-dose furosemide and carperitide for treating acute decompensated heart failure: a single-center retrospective cohort study.盐与小剂量呋塞米和卡培立肽治疗急性失代偿性心力衰竭的比较：一项单中心回顾性队列研究。
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Urinary composition predicts diuretic efficiency of hypertonic saline solution with furosemide therapy and heart failure prognosis.尿液成分可预测呋塞米治疗高渗盐溶液的利尿效率及心力衰竭预后。
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Hypertonic saline plus i.v. furosemide improve renal safety profile and clinical outcomes in acute decompensated heart failure: A meta-analysis of the literature.高渗盐水联合静脉注射呋塞米可改善急性失代偿性心力衰竭患者的肾脏安全性和临床结局：一项文献荟萃分析
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本文引用的文献

1
Real World Use of Hypertonic Saline in Refractory Acute Decompensated Heart Failure: A U.S. Center's Experience.高渗盐水在难治性急性失代偿性心力衰竭中的实际应用：美国中心的经验。
JACC Heart Fail. 2020 Mar;8(3):199-208. doi: 10.1016/j.jchf.2019.10.012. Epub 2020 Feb 5.
2
Effects of hypertonic saline solution on body weight and serum creatinine in patients with acute decompensated heart failure.高渗盐溶液对急性失代偿性心力衰竭患者体重和血清肌酐的影响。
World J Cardiol. 2017 Aug 26;9(8):685-692. doi: 10.4330/wjc.v9.i8.685.
3
Hypertonic saline with furosemide for the treatment of acute congestive heart failure: a systematic review and meta-analysis.高渗盐水联合呋塞米治疗急性充血性心力衰竭：一项系统评价和荟萃分析。
Int J Cardiol. 2014 May 1;173(2):139-45. doi: 10.1016/j.ijcard.2014.03.020. Epub 2014 Mar 14.
4
The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries.心力衰竭住院患者的全球健康和经济负担：从心力衰竭住院登记中吸取的经验教训。
J Am Coll Cardiol. 2014 Apr 1;63(12):1123-1133. doi: 10.1016/j.jacc.2013.11.053. Epub 2014 Feb 5.
5
2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines.2013年美国心脏病学会基金会/美国心脏协会心力衰竭管理指南：美国心脏病学会基金会/美国心脏协会实践指南工作组报告
Circulation. 2013 Oct 15;128(16):e240-327. doi: 10.1161/CIR.0b013e31829e8776. Epub 2013 Jun 5.
6
Short-term effects of hypertonic saline solution in acute heart failure and long-term effects of a moderate sodium restriction in patients with compensated heart failure with New York Heart Association class III (Class C) (SMAC-HF Study).高渗盐水溶液在急性心力衰竭中的短期作用以及在纽约心脏协会分级 III 级（C 类）（SMAC-HF 研究）的代偿性心力衰竭患者中适度钠限制的长期作用。
Am J Med Sci. 2011 Jul;342(1):27-37. doi: 10.1097/MAJ.0b013e31820f10ad.
7
Diuretic combinations in refractory oedema states: pharmacokinetic-pharmacodynamic relationships.难治性水肿状态下的利尿剂联合应用：药代动力学-药效学关系
Clin Pharmacokinet. 1996 Mar;30(3):229-49. doi: 10.2165/00003088-199630030-00004.
8
Diuretic efficacy of high dose furosemide in severe heart failure: bolus injection versus continuous infusion.大剂量呋塞米在重度心力衰竭中的利尿疗效：静脉推注与持续静脉输注对比
J Am Coll Cardiol. 1996 Aug;28(2):376-82. doi: 10.1016/0735-1097(96)00161-1.
9
Combined therapy with thiazide-type and loop diuretic agents for resistant sodium retention.噻嗪类利尿剂与襻利尿剂联合治疗顽固性钠潴留。
Ann Intern Med. 1983 Sep;99(3):405-6. doi: 10.7326/0003-4819-99-3-405.
10
The physiologic basis of diuretic synergism: its role in treating diuretic resistance.利尿剂协同作用的生理基础：其在治疗利尿剂抵抗中的作用。
Ann Intern Med. 1991 May 15;114(10):886-94. doi: 10.7326/0003-4819-114-10-886.

急性失代偿性心力衰竭中的高渗盐水（HSHF）

Hypertonic saline in acute decompensated heart failure (HSHF).

作者信息

Agrawal Shweta, Abhishek Batta Sunil, Rao Tarun, Selvam Sumithra

机构信息

Department of Cardiology, St. John's medical college and hospital, Bangalore, India.

William Harvey Hospital, Ashford, Kent, England, UK.

出版信息

Indian Heart J. 2024 Nov-Dec;76(6):418-420. doi: 10.1016/j.ihj.2024.11.246. Epub 2024 Nov 22.

DOI:10.1016/j.ihj.2024.11.246
PMID:39579977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11705591/
Abstract

Hypertonic saline with high dose furosemide improves refractory heart failure. In this case series of 10 patients of refractory acute decompensated heart failure, effect of HSS with furosemide was compared with furosemide alone. Patients responded to the therapy better, with faster decongestion, without significant adverse effects or worsening renal function. Hence an adequately powered, randomized study is required to assess the veracity of findings in this case series of hypertonic saline in diuretic resistant acute decompensated heart failure on optimal therapy. Based on present study, hypertonic saline looks like a promising option in the management of refractory heart failure.

摘要

高渗盐水联合大剂量呋塞米可改善难治性心力衰竭。在这个包含10例难治性急性失代偿性心力衰竭患者的病例系列中，将高渗盐水联合呋塞米的效果与单用呋塞米进行了比较。患者对该治疗反应更好，消肿更快，且无明显不良反应或肾功能恶化。因此，需要进行一项样本量充足的随机研究，以评估该病例系列中关于高渗盐水治疗利尿剂抵抗性急性失代偿性心力衰竭的最佳疗法的研究结果的准确性。基于目前的研究，高渗盐水在难治性心力衰竭的治疗中似乎是一个有前景的选择。