Yang Fan, Mo Dong, Wu Beibei, Chen Jiahao, Liu Qinhui, Chen Wenfei, Pang Juan, Wang Wenjing, Jing Xiandan, Xiong Yimin, Yang Na, Xu Yining, Li Yanping, Huang Yuan, Mo Li, He Jinhan
Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
J Control Release. 2025 Jan 10;377:470-484. doi: 10.1016/j.jconrel.2024.11.047. Epub 2024 Nov 29.
Diabetic foot ulcers are linked to a high disability rate, with no effective treatment currently available. Addressing infection, reducing oxidative stress, and safely managing chronic inflammation remain major challenges. In this study, a composite hydrogel dressing was developed using natural substances or clinically approved components (dopamine, D-alpha-tocopheryl polyethylene glycol succinate, and rhein). Upon near-infrared laser irradiation, the composite system rapidly heats and solidifies into a gel with photothermal antibacterial properties. Additionally, the decomposition of hydrogen peroxide releases oxygen, alleviating wound hypoxia. The hydrogel exhibited strong bactericidal activity against multiple bacterial strains. Without laser irradiation, the hydrogel effectively scavenged various free radicals and intracellular reactive oxygen species, restoring redox balance. Furthermore, it significantly reduced the expression of inflammatory cytokines, including interleukin-6 and interleukin-1β. In a diabetic mouse wound model infected with S. aureus, the mild photothermal therapy, combined with the antibacterial action of rhein, effectively managed bacterial infections, reduced inflammation, and promoted wound healing. Consequently, the photo-controlled therapeutic approach, offering antibacterial, antioxidant, and anti-inflammatory effects, holds promise for the effective treatment and management of infected diabetic wounds.
糖尿病足溃疡与高致残率相关，目前尚无有效的治疗方法。应对感染、减轻氧化应激以及安全管理慢性炎症仍然是主要挑战。在本研究中，使用天然物质或临床批准的成分（多巴胺、聚乙二醇琥珀酸维生素E酯和大黄酸）开发了一种复合水凝胶敷料。在近红外激光照射下，复合体系迅速升温并固化成具有光热抗菌性能的凝胶。此外，过氧化氢的分解会释放氧气，缓解伤口缺氧。该水凝胶对多种细菌菌株表现出强大的杀菌活性。在无激光照射的情况下，水凝胶能有效清除各种自由基和细胞内活性氧，恢复氧化还原平衡。此外，它还显著降低了包括白细胞介素-6和白细胞介素-1β在内的炎症细胞因子的表达。在感染金黄色葡萄球菌的糖尿病小鼠伤口模型中，温和的光热疗法与大黄酸的抗菌作用相结合，有效控制了细菌感染，减轻了炎症，并促进了伤口愈合。因此，这种光控治疗方法具有抗菌、抗氧化和抗炎作用，有望有效治疗和管理感染性糖尿病伤口。
