Zhang Jia Lin, Liao Guan-Yu, Lin Hong-Yi, Xie Jie-An, Li Wan-Chen, Chen Huang-Chi, Wu Da Wei, Juan Huai-Lei, Kuo Jia-Yu, Chen Pei-Shih
Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung City, Taiwan, ROC.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
J Hazard Mater. 2025 Jan 15;482:136573. doi: 10.1016/j.jhazmat.2024.136573. Epub 2024 Nov 20.
Air purifiers can enhance indoor air quality and health outcomes, and studies have primarily focused on filters and particulate matter (PM) in households. Photocatalytic oxidation (PCO) is a promising technique for eliminating gaseous pollutants and bioaerosols. However, no field study was conducted in household. Therefore, this study evaluated the effects of the PCO and PCO + filters intervention on indoor air pollutants and cardiopulmonary endpoints in households.
A randomized, double-blind crossover clinical trial was conducted. Indoor air pollutants, including PM, bioaerosols, and gaseous pollutants and cardiopulmonary endpoints including lung function, fractional exhaled nitric oxide (FeNO), respiratory symptoms, and blood pressure were assessed before and after intervention.
This was the first study to evaluate the effects of PCO and PCO + filters interventions on indoor air pollutants and cardiopulmonary health in households. Indoor total volatile organic compounds (TVOC) and sulfur dioxides (SO) significantly reduced after PCO intervention, however, we also observed the significant reduction in percentage of predicted values of forced vital capacity (FVC%) and forced expiratory volume in 3 s (FEV%) and increased in FeNO after 13 days of PCO intervention. The PCO + filters intervention significantly reduced the levels of indoor PM, PM, PM, PM, total suspended particulate matter, ultrafine particles, airborne bacteria, fungi, endotoxin, mites, TVOC, nitrogen dioxide, and SO, and marginal reduction in carbon monoxide. However, indoor carbon dioxide significantly increased after PCO/PCO + filters intervention. As for cardiopulmonary health, FVC%, and FEV1 % marginally increased 7 days after the PCO + filters intervention.
空气净化器可改善室内空气质量并对健康有益，此前的研究主要聚焦于家庭中的过滤器和颗粒物（PM）。光催化氧化（PCO）是一种很有前景的消除气态污染物和生物气溶胶的技术。然而，尚未有针对家庭环境的实地研究。因此，本研究评估了PCO和PCO +过滤器干预对家庭室内空气污染物和心肺指标的影响。
开展了一项随机、双盲交叉临床试验。在干预前后评估室内空气污染物，包括PM、生物气溶胶和气态污染物，以及心肺指标，包括肺功能、呼出一氧化氮分数（FeNO）、呼吸道症状和血压。
这是第一项评估PCO和PCO +过滤器干预对家庭室内空气污染物和心肺健康影响的研究。PCO干预后，室内总挥发性有机化合物（TVOC）和二氧化硫（SO）显著减少，然而，我们也观察到在PCO干预13天后，用力肺活量预测值百分比（FVC%）和3秒用力呼气量（FEV%）显著降低，FeNO增加。PCO +过滤器干预显著降低了室内PM、PM、PM、PM、总悬浮颗粒物、超细颗粒、空气传播细菌、真菌、内毒素、螨虫、TVOC、二氧化氮和SO的水平，一氧化碳略有降低。然而，PCO/PCO +过滤器干预后室内二氧化碳显著增加。至于心肺健康，PCO +过滤器干预7天后，FVC%和FEV1%略有增加。
