Gao Wei Xiang, Liu Jia, Wang Jiao, Jin Ya Li, Yeung Shiu Lun Au, Lam Tai Hing, Zhang Wei Sen, Xu Lin
School of public health, Sun Yat-sen University, Guangzhou 510080, China; Greater Bay Area Public Health Research Collaboration, Guangdong-Hong Kong-Macao, China.
Guangzhou Twelfth People's Hospital, Guangzhou 510620, China.
Arch Gerontol Geriatr. 2025 Feb;129:105687. doi: 10.1016/j.archger.2024.105687. Epub 2024 Nov 9.
The World Health Organization introduced intrinsic capacity (IC) as a metric for healthy aging. However, we found no report on the association between IC and type 2 diabetes mellitus (T2DM). We investigated the association between IC and incident T2DM in older Chinese from the Guangzhou Biobank Cohort Study.
IC was assessed across five domains equally: locomotion, vitality, cognition, psychological and sensory. Composite IC scores (0-10) were classified into three groups: poor (0-5.9), fair (6.0-8.9), and high (9.0-10), with higher scores representing greater IC. Multivariable linear regression and cox regression was used to analyze the association between IC with glycemia and T2DM, respectively.
Of 3582 participants with a mean age of 59.1 years (standard deviation (SD)=7.13) without baseline diabetes, during an average follow-up of 3.3 years (SD=0.86), 497 (13.87%) developed T2DM. After adjustments for potential confounders, those with baseline poor IC, versus high, had higher fasting glucose, 2-hour post-load glucose and glycosylated hemoglobin A at follow-up, and a higher risk of incident T2DM (HR (95%CI): 1.80 (1.20, 2.72)). Among IC domains, only vitality impairment was associated with an increased risk of T2DM (P for trend < 0.001).
We first reported the prospective associations of poor IC and vitality with higher glycemia and incident T2DM risk. Enhancing muscle strength to improve functional ability may be a possible intervention for reducing future risk of T2DM in older populations.
世界卫生组织引入内在能力（IC）作为健康老龄化的一项指标。然而，我们未发现关于IC与2型糖尿病（T2DM）之间关联的报告。我们在广州生物银行队列研究中调查了中国老年人群中IC与新发T2DM之间的关联。
IC通过五个领域进行同等评估：运动能力、活力、认知、心理和感官。综合IC评分（0 - 10分）分为三组：差（0 - 5.9分）、中等（6.0 - 8.9分）和高（9.0 - 10分），分数越高表示IC越强。分别使用多变量线性回归和Cox回归分析IC与血糖及T2DM之间的关联。
在3582名平均年龄为59.1岁（标准差（SD）=7.13）且无基线糖尿病的参与者中，平均随访3.3年（SD = 0.86）期间，497人（13.87%）发生了T2DM。在对潜在混杂因素进行调整后，基线IC差的参与者与IC高的参与者相比，随访时空腹血糖、负荷后2小时血糖和糖化血红蛋白A更高，且发生T2DM的风险更高（风险比（95%置信区间）：1.80（1.20，2.72））。在IC的各个领域中，只有活力受损与T2DM风险增加相关（趋势P值<0.001）。
我们首次报告了IC差和活力与更高血糖及新发T风险之间的前瞻性关联。增强肌肉力量以提高功能能力可能是降低老年人群未来T2DM风险的一种可能干预措施。 2DM
