Hartz A J, Fischer M E, Bril G, Kelber S, Rupley D, Oken B, Rimm A A
J Chronic Dis. 1986;39(4):311-9. doi: 10.1016/0021-9681(86)90053-6.
Data from 4225 persons from the National Health and Nutrition Examination Survey (HANES) was used to determine whether obesity was associated with osteoarthritis (OA) or joint pain. Subjects were divided into four groups on the basis of sex and race. We found that obesity was associated with OA of the knee for each sex/race group (p less than 0.01). The association was strongest for women, and it was present even for subjects without evidence of knee pain on physical examination. Frame size was not significantly associated with OA of the knee. Relative weight was weakly associated with OA of the hips in white women and nonwhite men but not significantly associated with OA of the sacroiliac joint. Diabetes did not seem to be an important risk factor for OA. These results suggest that the additional mechanical stress resulting from obesity is the principal reason for the association between obesity and OA.
来自美国国家健康与营养检查调查（HANES）的4225人的数据被用于确定肥胖是否与骨关节炎（OA）或关节疼痛有关。受试者根据性别和种族分为四组。我们发现，每个性别/种族组中肥胖都与膝关节OA相关（p小于0.01）。这种关联在女性中最为明显，即使在体格检查中没有膝关节疼痛证据的受试者中也存在。体型与膝关节OA没有显著关联。相对体重与白人女性和非白人男性的髋关节OA有弱关联，但与骶髂关节OA没有显著关联。糖尿病似乎不是OA的重要危险因素。这些结果表明，肥胖导致的额外机械应力是肥胖与OA之间关联的主要原因。
