Sihota Davneet, Lee Him Rachel, Dominguez Georgia, Harrison Leila, Vaivada Tyler, Bhutta Zulfiqar Ahmed
Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
Center of Excellence in Women and Child Health, Aga Khan University, Karachi, Pakistan.
Neonatology. 2025;122(Suppl 1):52-83. doi: 10.1159/000542539. Epub 2024 Nov 22.
To describe recent evidence regarding the most effective neonatal resuscitation training program and scale-up of these programs in low- and middle-income countries (LMICs), which has contributed to the upcoming Lancet Global Newborn Care Series 2025, and forms part of a supplement describing an extensive synthesis on effective newborn interventions in LMICs.
We included relevant studies from Medline, Embase, CINAHL, Cochrane CENTRAL and Global Index Medicus databases on the effectiveness and scale-up of Neonatal Resuscitation Training Programs (NRTP), with searches run August 2022. Data extraction and quality assessments were completed independently and in duplicate.
A total of 93 unique records met the eligibility criteria and were included in our analyses across the reviews. NRTPs improved most knowledge and skill-based outcomes but impact on mortality varied. Included studies identified knowledge and skill retention, standardized training protocols, and limited training opportunities for health care providers as challenges to current NRTPs.
Reported knowledge, skills, and mortality outcomes were similar across NRTPs. The Helping Babies Breathe (HBB) program was found to be cost-effective in Tanzania, suggesting that the HBB program or elements thereof are low-cost and scalable in LMICs. Future research across diverse settings should evaluate the cost-effectiveness of other NRTPs. To scale-up current NRTPs, programs should focus on improving long-term retention outcomes and improving training material accessibility.
To describe recent evidence regarding the most effective neonatal resuscitation training program and scale-up of these programs in low- and middle-income countries (LMICs), which has contributed to the upcoming Lancet Global Newborn Care Series 2025, and forms part of a supplement describing an extensive synthesis on effective newborn interventions in LMICs.
We included relevant studies from Medline, Embase, CINAHL, Cochrane CENTRAL and Global Index Medicus databases on the effectiveness and scale-up of Neonatal Resuscitation Training Programs (NRTP), with searches run August 2022. Data extraction and quality assessments were completed independently and in duplicate.
A total of 93 unique records met the eligibility criteria and were included in our analyses across the reviews. NRTPs improved most knowledge and skill-based outcomes but impact on mortality varied. Included studies identified knowledge and skill retention, standardized training protocols, and limited training opportunities for health care providers as challenges to current NRTPs.
Reported knowledge, skills, and mortality outcomes were similar across NRTPs. The Helping Babies Breathe (HBB) program was found to be cost-effective in Tanzania, suggesting that the HBB program or elements thereof are low-cost and scalable in LMICs. Future research across diverse settings should evaluate the cost-effectiveness of other NRTPs. To scale-up current NRTPs, programs should focus on improving long-term retention outcomes and improving training material accessibility.
描述有关最有效的新生儿复苏培训计划以及在低收入和中等收入国家（LMIC）扩大这些计划规模的最新证据，这些证据为即将出版的《柳叶刀》2025年全球新生儿护理系列做出了贡献，并且是一份关于LMIC有效新生儿干预措施广泛综合描述的补充材料的一部分。
我们纳入了来自Medline、Embase、CINAHL、Cochrane CENTRAL和全球医学索引数据库中关于新生儿复苏培训计划（NRTP）有效性和扩大规模的相关研究，检索时间为2022年8月。数据提取和质量评估由两人独立完成且结果一致。
共有93条独特记录符合纳入标准，并纳入我们的综合分析。NRTP改善了大多数基于知识和技能的结果，但对死亡率的影响各不相同。纳入的研究指出，知识和技能的保留、标准化培训方案以及医疗保健提供者的培训机会有限是当前NRTP面临的挑战。
各NRTP报告的知识、技能和死亡率结果相似。在坦桑尼亚发现“帮助婴儿呼吸”（HBB）计划具有成本效益，这表明HBB计划或其部分内容在LMIC中成本较低且可扩展。未来在不同环境下的研究应评估其他NRTP的成本效益。为扩大当前NRTP的规模，各计划应专注于改善长期保留效果并提高培训材料的可及性。
描述有关最有效的新生儿复苏培训计划以及在低收入和中等收入国家（LMIC）扩大这些计划规模的最新证据，这些证据为即将出版的《柳叶刀》2025年全球新生儿护理系列做出了贡献，并且是一份关于LMIC有效新生儿干预措施广泛综合描述的补充材料的一部分。
我们纳入了来自Medline、Embase、CINAHL、Cochrane CENTRAL和全球医学索引数据库中关于新生儿复苏培训计划（NRTP）有效性和扩大规模的相关研究，检索时间为2022年8月。数据提取和质量评估由两人独立完成且结果一致。
共有93条独特记录符合纳入标准，并纳入我们的综合分析。NRTP改善了大多数基于知识和技能的结果，但对死亡率的影响各不相同。纳入的研究指出，知识和技能的保留、标准化培训方案以及医疗保健提供者的培训机会有限是当前NRTP面临的挑战。
各NRTP报告的知识、技能和死亡率结果相似。在坦桑尼亚发现“帮助婴儿呼吸”（HBB）计划具有成本效益，这表明HBB计划或其部分内容在LMIC中成本较低且可扩展。未来在不同环境下的研究应评估其他NRTP的成本效益。为扩大当前NRTP的规模，各计划应专注于改善长期保留效果并提高培训材料的可及性。
