Johansson Alban, Ho Nicole Pui-Yu, Takizawa Hitoshi
Laboratory of Stem Cell Stress, International Research Center for Medical Sciences, Kumamoto University, Japan.
Laboratory of Stem Cell Stress, International Research Center for Medical Sciences, Kumamoto University, Japan; Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Japan.
Exp Hematol. 2025 Jan;141:104685. doi: 10.1016/j.exphem.2024.104685. Epub 2024 Nov 22.
The microbiome is a highly complex and diverse symbiotic component that undergoes dynamic changes with the organismal aging. Microbial perturbations, termed dysbiosis, exert strong influence on dysregulating the bone marrow niche and subsequently promoting the aging of hematopoietic and immune system. Accumulating studies have revealed the substantial impact of intestinal microbiome on the initiation and progression of age-related hematologic alteration and diseases, such as clonal hematopoiesis and blood cancers. Current therapeutic approaches to restore the altered microbiome diversity target specific pathobionts and are demonstrated to improve clinical outcomes of antihematologic malignancy treatments. In this review, we discuss the interplay between the microbiome and the hemato-immune system during aging process. We also shed light on the emerging therapeutic strategies to tackle the dysbiosis for amelioration of aging and disease progression.
微生物组是一个高度复杂且多样的共生成分，会随着机体衰老而发生动态变化。被称为生态失调的微生物扰动，对破坏骨髓生态位并随后促进造血和免疫系统衰老具有强大影响。越来越多的研究揭示了肠道微生物组对与年龄相关的血液学改变和疾病（如克隆性造血和血癌）的发生和发展的重大影响。目前恢复改变的微生物组多样性的治疗方法针对特定的致病共生菌，并已证明可改善抗血液恶性肿瘤治疗的临床结果。在这篇综述中，我们讨论了衰老过程中微生物组与血液免疫系统之间的相互作用。我们还阐明了针对生态失调以改善衰老和疾病进展的新兴治疗策略。
